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Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis.
P C Lee
1 ,
Z L Wang ,
S Qian ,
S C Watkins ,
A Lizonova ,
I Kovesdi ,
E Tzeng ,
R L Simmons ,
T R Billiar ,
L L Shears
Mar 27 2000
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Abstract
Inducible nitric oxide synthase (iNOS) is up-regulated in rejecting allografts and is protective against allograft arteriosclerosis; it suppresses neointimal smooth muscle cell accumulation and inhibits adhesion of platelets and leukocytes to the endothelium. However, the functional importance of endothelial NOS (eNOS) in the rejecting allografts remains unclear.