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Outcome of Pregnancy in Women With Congenital Heart Disease
Willem Drenthen ,
Petronella G. Pieper ,
Jolien W. Roos-Hesselink ,
Willem A. van Lottum ,
Adriaan A. Voors ,
Barbara J.M. Mulder ,
Arie P.J. van Dijk ,
Hubert W. Vliegen ,
Sing C. Yap ,
Philip Moons ,
Tjark Ebels ,
Dirk J. van Veldhuisen
June 2007
June 2007
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Abstract
A search of peer-reviewed literature was conducted to identify reports that provide
data on complications associated with pregnancy in women with structural congenital
heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including
377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications
were seen in 11% of the pregnancies. Obstetric complications do not appear to be more
prevalent. In complex CHD, premature delivery rates are high, and more children are
small for gestational age. The offspring mortality was high throughout the spectrum
and was related to the relatively high rate of premature delivery and recurrence of
CHD.