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Long-acting injectable aripiprazole in pregnant women with schizophrenia: a case-series report
case-report
Author(s):
Blanca Fernández-Abascal ,
Maria Recio-Barbero ,
Margarita Sáenz-Herrero ,
Rafael Segarra
Publication date (Electronic):
31 January 2021
Publisher:
SAGE Publications
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Abstract
Antipsychotic long-acting formulations (LAI-AP) have emerged as a new therapeutic choice to treat patients presenting a severe mental disorder. Despite that, to date, there is a lack of safety data and studies regarding the use of LAI-AP formulations in pregnant women. Here we present the first six-case series of pregnant women with schizophrenia treated with aripiprazole-LAI reported in the literature. All patients remained psychopathologically stable through pregnancy and the postpartum period, and all of them were in treatment with aripiprazole-LAI. To date, all infants remain healthy with normal developmental milestones, without the presence of congenital malformations or adverse effects. Lack of information on safety data regarding the use of new antipsychotic formulations remains important in treating women with mental illness who desire to become pregnant. Further studies in this clinical population with a larger number of patients included remains necessary.
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Most cited references55
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Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis.
Leanne Bellamy, Juan-Pablo Casas, Aroon D Hingorani … (2009)
Women with gestational diabetes are at increased risk of developing type 2 diabetes, but the risk and time of onset have not been fully quantified. We therefore did a comprehensive systematic review and meta-analysis to assess the strength of association between these conditions and the effect of factors that might modify the risk. We identified cohort studies in which women who had developed type 2 diabetes after gestational diabetes were followed up between Jan 1, 1960, and Jan 31, 2009, from Embase and Medline. 205 relevant reports were hand searched. We selected 20 studies that included 675 455 women and 10 859 type 2 diabetic events. We calculated and pooled unadjusted relative risks (RRs) with 95% CIs for each study using a random-effects model. Subgroups analysed were the number of cases of type 2 diabetes, ethnic origin, duration of follow-up, maternal age, body-mass index, and diagnostic criteria. Women with gestational diabetes had an increased risk of developing type 2 diabetes compared with those who had a normoglycaemic pregnancy (RR 7.43, 95% CI 4.79-11.51). Although the largest study (659 164 women; 9502 cases of type 2 diabetes) had the largest RR (12.6, 95% CI 12.15-13.19), RRs were generally consistent among the subgroups assessed. Increased awareness of the magnitude and timing of the risk of type 2 diabetes after gestational diabetes among patients and clinicians could provide an opportunity to test and use dietary, lifestyle, and pharmacological interventions that might prevent or delay the onset of type 2 diabetes in affected women. None.
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Domestic Violence and Perinatal Mental Disorders: A Systematic Review and Meta-Analysis
Louise Howard, Siân Oram, Helen Galley … (2013)
Introduction Perinatal mental disorders are among the commonest health problems associated with pregnancy and the postpartum period. Antenatal disorders (including depression and anxiety disorders, eating disorders, and psychoses) are associated with adverse effects on the fetus including low birth weight and pre-term delivery [1]–[3], perinatal and infant death [4]–[6], and postnatal psychopathology [7]–[9], with the last associated with subsequent behavioural/emotional problems in the child and adolescent [10]. Risk factors for most perinatal mental disorders are generally similar to those for mental disorders outside the perinatal period and include a family and personal history of mental disorders [11],[12]. Previous research has found an association between mental disorder and being a victim of domestic violence (i.e., intimate partner violence and/or violence perpetrated by another family member) that is not diagnostically specific; associations have been found for common mental disorders, eating disorders, and psychosis and domestic violence in non-perinatal populations [13],[14]. The prevalence of domestic violence during pregnancy in high-income settings ranges from 4% to 8% in the majority of studies, equating to approximately 152,000 to 324,000 pregnant women experiencing abuse each year in the US [15],[16], in low- and middle-income countries the prevalence can be higher [17]. There is strong evidence that domestic violence increases the risk of low birth weight, and growing evidence of an association with pre-term labour, miscarriage, fetal death [18], and subsequent child behavioural problems [19]; domestic violence can also be a cause of maternal death [20]–[22]. The recent UK Confidential Enquiry into Maternal Deaths highlighted that domestic-violence-related deaths were perpetrated by both in-laws and partners [22]. Recent reviews have indicated a possible association between perinatal mental disorder and having experienced domestic violence, but these reviews have the following limitations: they identified only a limited number of relevant studies (<10); they focused predominantly on depression and not the full range of antenatal and postnatal mental disorders; they did not disaggregate findings according to whether violence was reported during pregnancy, during the past year, or over the lifetime; and they did not restrict their analyses to studies that used diagnostic or validated screening instruments to assess mental disorder [23]–[26]. Our systematic review aimed to address these limitations to provide more robust estimates of the following: (a) the prevalence of having experienced domestic violence (lifetime, past year, and during pregnancy) among women with antenatal and postnatal mental disorders (depression and anxiety disorders including post-traumatic stress disorder [PTSD], eating disorders, and psychoses including puerperal psychosis), (b) the odds of having experienced domestic violence (lifetime, past year, and during pregnancy) among women with antenatal and postnatal mental disorders (depression and anxiety disorders, eating disorders, and psychoses including puerperal psychosis), and (c) the odds of incident antenatal and postnatal mental disorders subsequent to having experienced domestic violence and the odds of experiencing domestic violence in women with pre-existing antenatal or postnatal disorders. Methods Search Strategy This review followed MOOSE and PRISMA guidelines (see Text S1), and the protocol (see Text S2) is registered with the PROSPERO database of systematic reviews (http://www.crd.york.ac.uk/prospero; registration number CRD42011001281) [27],[28]. The search strategy comprised an electronic search of bibliographic databases, an update of a recent systematic review on the victimisation of people with mental disorders [29], hand searches of three key journals (Trauma Violence and Abuse, Journal of Traumatic Stress, and Violence Against Women), backwards and forwards citation tracking, and expert recommendations. Medical Subject Headings (MeSH) and text words were used to search 18 electronic databases, from their dates of inception up to 31 March 2011 (see Box 1 for the list of databases searched). Additional searches of Medline, Embase, and PsycINFO, and hand searches of Trauma Violence and Abuse, Journal of Traumatic Stress, and Violence Against Women, were conducted for the period 1 January 2011 to 15 February 2013. Terms for domestic violence were adapted from Cochrane protocols and peer-reviewed literature reviews, and terms for mental disorders were adapted from NICE guidelines [30]–[32]. The search strategy for Medline, Embase, and PsycINFO is shown in Text S3. When updating the victimisation review, we used the author's original search terms to search databases from September 2007 (the upper limit of the original review) to 31 March 2011. No language restrictions were used. Box 1 Biomedical databases: Academic Search Complete, BNI (British Nursing Index), CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane, Embase, HMIC (Health Management Information Consortium), Medline, Maternity and Infant Care, PsycINFO, Science Direct, Web of Science (including SCI, SSCI, A&HCI, CPCI-S, CPCI-SSH). Social sciences databases: Applied Social Sciences Index and Abstracts, International Bibliography of the Social Sciences, JSTOR, Sociological Abstracts. Theses and dissertations: DART-Europe E-Theses Portal, EThOS, Networked Digital Library of Theses and Dissertations Selection Criteria Studies were eligible for inclusion if they (a) included women who were 16 y or older and were assessed as having a perinatal mental disorder using a validated diagnostic instrument or screening instrument; (b) presented the results of peer-reviewed research based on experimental studies (e.g., randomised controlled trials, non-randomised controlled trials, parallel group studies), before-and-after studies, interrupted time series studies, cohort studies, case-control studies, or cross-sectional studies; and (c) measured the prevalence or odds of having experienced domestic violence during the lifetime, during the past year, (i.e., 12 mo prior to interview regardless of whether this was in the antenatal or postnatal period), or during pregnancy. When we identified multiple eligible papers from the same study, only the paper reporting the largest sample size was included. Data Extraction and Quality Appraisal Two reviewers (S. O. and K. T.) screened the downloaded titles and abstracts against the inclusion criteria; if it was unclear whether a reference met the inclusion criteria, it was taken forward to the next stage of screening. Two reviewers (S. O. and K. T.) assessed the full texts of potentially eligible studies. If studies collected data on the prevalence and/or odds of domestic violence but did not report it, authors were contacted for further information. Data from included papers were extracted into an electronic database by two reviewers (S. O. and H. G.). Extracted data included details of the study design, sample characteristics, measures of mental disorder and domestic violence, and the prevalence and odds of domestic violence victimisation. Details on the type of violence and chronicity of mental disorders were extracted where reported. The quality of included studies was independently appraised by two reviewers (S. O. and H. G.) using criteria adapted from validated tools [33]. Reviewers compared scores and resolved disagreements before allocating a final appraisal score. The quality appraisal checklist (see Text S4) included items assessing study selection and measurement biases; studies were categorised as high quality if they scored ≥50% on questions pertaining to selection bias. Data Analysis Prevalence, odds ratios (ORs), and 95% confidence intervals of having experienced domestic violence were calculated by type of perinatal mental disorder. If a study measured one disorder only (e.g., depression), the control group for the calculation of ORs was women without that disorder. If a study measured multiple disorders (e.g., depression and anxiety), the control group was women without those disorders. This reduced the risk of control groups including women with mental disorders, and improved consistency where studies contributed data for several mental disorders. Prevalence and unadjusted ORs were also calculated separately by period of violence experienced (lifetime, past year, and during pregnancy). We report prevalence estimates and ORs for having experienced “any violence” (i.e., any physical, sexual, or psychological violence). There were limited disaggregated data providing the prevalence and odds of having experienced physical, sexual, and psychological violence separately; these are reported in Table S1 (cross-sectional studies) and Table S2 (longitudinal studies).When analysing longitudinal data, we examined both the association between recent experiences of domestic violence at baseline and mental disorder identified at follow-up, and the association between mental disorder at baseline and domestic violence experienced during the follow-up period. Pooled unadjusted OR estimates (with corresponding 95% confidence intervals) were calculated using random effects meta-analysis if data were available from three or more studies. We examined the influence of individual studies on summary effect estimates by conducting influence analyses, which compute summary estimates omitting one study at a time. We aimed to assess the risk of small study bias with funnel plots (see Figure S1) [34]. Because of the small number of eligible studies, statistical tests for funnel plot asymmetry were not appropriate, and we were confined to visual inspection of the plots. Heterogeneity among studies was estimated using the I 2 statistic. Pooled population attributable fraction (PAF) estimates were calculated using data from longitudinal studies, based on meta-analysis-derived summary relative risks. All analyses were conducted in Stata 11 [35]. Only studies that assessed mental disorders using either validated diagnostic instruments or validated screening instruments with the recommended cutoff scores were included in median prevalence and pooled OR calculations. Studies that used the Patient Health Questionnaire were excluded from these calculations because of the low sensitivity and specificity of the Patient Health Questionnaire in perinatal populations [36]. Where sufficient data were available, pooled ORs were also calculated that included only studies that used the Edinburgh Postnatal Depression Scale to measure probable depression (high levels of depressive symptoms), as this instrument is the most widely used internationally and has been validated in 32 languages [37]. Results The study selection process is presented in Figure 1. The literature search yielded 30,563 unique references, of which 29,469 were excluded following title and abstract screening. Of the 1,184 references that met, or potentially met, the inclusion criteria, 59 could not be located. Thus, 1,125 full papers were retrieved and assessed. Of these, 67 papers were included in the review following full-text screening; 55 were identified from searches of electronic databases, two from citation tracking, three from hand searching, and seven from expert recommendations. 10.1371/journal.pmed.1001452.g001 Figure 1 Flow diagram of screened and included papers. Key Features of Included Studies A summary of included studies is shown in Table 1 [19],[38]–[103]. Individual details of all included studies, including outcomes and quality appraisal scores, are reported by disorder in Table S1 (cross-sectional data) and Table S2 (longitudinal data). Forty studies were categorised as high quality. Unless otherwise stated, the omission of individual studies during sensitivity analyses did not materially affect pooled ORs. Pooled ORs calculated using only studies that used the Edinburgh Postnatal Depression Scale were also not materially different to the pooled ORs calculated using all eligible studies, unless otherwise stated. 10.1371/journal.pmed.1001452.t001 Table 1 Summary of included studies (n = 67). Characteristic Longitudinal Studies (n = 16) Cross Sectional Studies (n = 56) Total (n = 67) Diagnosis Depression 16 45 56 Anxiety 1 4 5 PTSD 0 4 4 Psychological distress 0 10 10 Recency of violence Lifetime 7 25 31 Past year 5 22 25 During pregnancy 5 19 22 Perpetrator of violence Partner or spouse 16 56 67 Family member 1 8 9 Type of violence Physical 5 18 21 Psychological 3 15 17 Sexual 2 6 8 Physical, sexual, or psychological (combined) 10 41 48 Setting Clinical only 1 34 34 Non-clinical only 6 22 26 Clinical and non-clinical 9 0 9 Region North America 4 21 22 Central America 0 0 0 South America 2 7 9 Europe 2 6 7 Middle East 1 3 4 Africa 0 1 1 Asia 6 13 19 Australasia 1 5 5 Categories are not mutually exclusive, and row totals may therefore add to more than 67. Studies may contribute both longitudinal and cross-sectional data; column totals may therefore be less than the sum of the longitudinal and cross-sectional data columns. Findings from Cross-Sectional Data As shown in Table 2, median prevalence and pooled ORs showed that women with probable depression in the antenatal period reported a high prevalence and increased odds of having experienced intimate partner violence during the lifetime (OR 3.0, 95% CI 2.3–4.0, I 2 51.1%), during the past year (OR 2.8, 95% CI 1.5–5.3, I 2 75.3%), and during pregnancy (OR 5.0, 95% CI 4.0–6.2, I 2 23.7%) (see also Figures 2–4). The heterogeneity for having experienced intimate partner violence during the lifetime was substantially reduced when omitting two studies that used the Hospital Anxiety and Depression Scale (OR 3.3, 95% CI 2.7–4.0, I 2 11.2%). Median prevalence and pooled ORs also showed that women with probable depression in the postnatal period reported a high prevalence and increased odds of having experienced intimate partner violence during the lifetime (OR 2.9, 95% CI 1.8–4.8, I 2 77.6%), during the past year (OR 2.8, 95% CI 1.7–4.6, I 2 79.2%), and during pregnancy (OR 4.4, 95% CI 2.9–6.5, I 2 22.4%) (see also Figures 5–7). 10.1371/journal.pmed.1001452.g002 Figure 2 Meta-analysis of the association between antenatal depression and any lifetime domestic violence (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.g003 Figure 3 Meta-analysis of the association between antenatal depression and any past year partner violence (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.g004 Figure 4 Meta-analysis of the association between antenatal depression and partner violence during pregnancy (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.g005 Figure 5 Meta-analysis of the association between postnatal depression and any lifetime partner violence (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.g006 Figure 6 Meta-analysis of the association between postnatal depression and any past year partner violence (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.g007 Figure 7 Meta-analysis of the association between postnatal depression and partner violence during pregnancy (cross-sectional studies). ES, effect size. 10.1371/journal.pmed.1001452.t002 Table 2 Summary of findings from cross-sectional studies. Disorder Lifetime Domestic Violence Past-Year Domestic Violence Domestic Violence during Pregnancy Median Prevalence Pooled OR Individual ORs Where Pooled OR Could Not Be Calculated Median Prevalence Pooled OR Individual ORs Where Pooled OR Could Not Be Calculated Median Prevalence Pooled OR Individual ORs Where Pooled OR Could Not Be Calculated Disorder in the antenatal period Depression 38.9% (IQR 35.2%–51.3%, range 15.2%–72.2%) [41],[44],[57],[66],[68],[69],[82],[84],[92],[96],[97],[99],[103] 3.0 (95% CI 2.3–4.0, I 2 51.1%) [41],[44],[57],[66],[68],[69],[82],[84],[96],[97],[103] n/a 29.9% (IQR 21.8%–45.1%, range 4.8%–46.1%) [49],[52],[62],[63],[67],[71],[91],[96] 2.8 (95% CI 1.5–5.3, I 2 75.3%) [52],[62],[67],[91],[96] n/a 14.4% (IQR 13.2%–25.7%, range 8.6%–88.4%) [19],[44],[52],[57],[67],[79],[96] 5.0 (95% CI 4.0–6.2, I 2 23.7%) [19],[52],[57],[67],[79],[83],[96] n/a Anxiety 29.8% (IQR 28.8%–53.1%, range 28.8%–53.1%) [41],[68],[99] — Ali et al. [41] (OR 0.5, 95% CI 0.2–1.4); Jundt et al. [68] (OR 2.1, 95% CI 1.1–4.0) — — — — — — PTSD — — Mezey et al. [82] (OR 6.4, 95% CI 1.7–26.4) — — Seng et al. [95] (OR 4.6, 95% CI 2.5–8.5) — — Seng et al. [95] (OR 6.0, 95% CI 1.4–29.2) Disorder in the postnatal period Depression 28.5% (IQR 23.7%–36.3%, range 8.9%–83.6%) [39],[42],[50],[51],[64],[89] 2.9 (95% CI 1.8–4.8, I 2 77.6%) [42],[50],[51],[64],[81],[89] n/a 26.7% (IQR 20.1%–45.9%. range 5.7%–97.9%) [42],[43],[46],[47],[49],[56],[65],[100] 2.8 (95% CI 1.7–4.6, I 2 79.2%) [42],[46],[47],[56],[100] n/a — 4.4 (95% CI 2.9–6.5, I 2 22.4%) [38],[75],[89] n/a Anxiety — — DeKlyen et al. [50] (OR 5.6, 95% CI 3.2–9.7) — — — — — — PTSD — — — — — Cerulli et al. [47] (OR 4.6, 95% CI 1.1–18.4) — — — n/a, not applicable. Two studies measured experiences of family violence (including violence from a partner) among women with probable depression in the antenatal period, reporting prevalence estimates of 35.2% and 38.9% [66],[99]. ORs could be calculated for only one study, which reported an increased odds of ever having experienced domestic violence (including from a partner) among women with probable depression in the antenatal period (OR 2.6, 95% CI 1.3–5.2) [66]. One study measured experiences of domestic violence (including violence from a partner) among women with probable depression in the postnatal period and found increased odds of having experienced past-year violence compared to women without probable depression (OR 2.9, 95% CI 1.5–5.7) [74]. Data were limited on the prevalence and odds of having experienced domestic violence among women with probable anxiety disorder or PTSD in either the antenatal or postnatal period. The prevalence of having experienced intimate partner violence during the lifetime was reported by two studies to be 27.8% and 29.8% among women with probable anxiety in the antenatal period [68],[99], and by one study to be 27.6% for women with diagnosed anxiety disorder in the postnatal period [50]. Individual studies reported non-significant increases in the odds of having experienced lifetime partner violence among women with probable anxiety in the antenatal period (OR 2.9, 95% CI 0.9–8.4) [68] and among women with anxiety disorder at 12 mo postpartum (OR 1.4, 95% CI 1.0–2.1) [50], compared to women with no anxiety [41]. Studies suggested that women with probable PTSD in the antenatal period had an increased risk of having experienced intimate partner violence during the lifetime (OR 6.4, 95% CI 1.7–26.4) [82], during the past year (OR 4.6, 95% CI 2.5–8.5) [92],[95], and during pregnancy 6.0 (95% CI 1.4–29.2) [92],[95]. Only one study measured experiences of intimate partner violence among women with PTSD in the postnatal period: Cerulli and colleagues reported increased odds of having experienced past-year intimate partner violence among women with PTSD (OR 4.6, 95% CI 1.1–18.4) and a prevalence of 41.2% [47]. One study measured having ever experienced domestic violence (including violence from a partner) among women with and without probable anxiety in the antenatal period [41]. The study, conducted in Pakistan, found no significant difference in the odds of having ever experienced violence between women with and without probable anxiety (OR 0.5, 95% CI 0.2–1.4); this lack of difference may be due to the very high levels of violence reported among women both with probable anxiety (76.4%) and without (86.0%) [41]. No studies measured violence perpetrated by family members among women with probable or diagnosed PTSD in the antenatal or postnatal period. No studies were found for other disorders in the antenatal or postnatal period. Findings from Longitudinal Data Longitudinal data were collected by 16 studies. Twelve studies assessed the association between antenatal violence and later probable depression. Pooled ORs found increased odds of probable postnatal depression among women who reported at baseline having ever experienced intimate partner violence (OR 2.9, 95% CI 2.0–4.0, I 2 0.0%) and among women who reported at baseline having experienced intimate partner violence during pregnancy (OR 3.1, 95% CI 2.7–3.6, I 2 0.0%) (see also Figures 8 and 9). Neither estimate could be adjusted for antenatal depression because of a lack of data. The pooled PAF estimate for probable depression during the postnatal period following experiences of intimate partner violence during pregnancy was 12.7% (95% CI 11.8%–13.6%). 10.1371/journal.pmed.1001452.g008 Figure 8 Meta-analysis of the association between any lifetime partner violence and postnatal depression (cohort studies). ES, effect size. 10.1371/journal.pmed.1001452.g009 Figure 9 Meta-analysis of the association between any partner violence during pregnancy and postnatal depression (cohort studies). Five studies assessed the association between probable antenatal depression and later experiences of intimate partner violence. Pooled ORs could not be calculated because of insufficient data, but individual studies reported that the odds of having experienced intimate partner violence during or up to a year after pregnancy were between two and five times higher among women with probable depression in the antenatal period compared to women without probable depression (not adjusted for baseline violence). One cohort study reported increased odds of lifetime intimate partner violence reported at 4 mo postpartum among women who had probable antenatal anxiety at baseline (OR 1.7, 95% CI 1.1–2.7); no longitudinal data were available for other disorders. Discussion Main Findings This systematic review and meta-analysis found that high levels of symptoms of all types of perinatal mental disorders included in studies to date (i.e., antenatal and postnatal anxiety, depression, and PTSD) were associated with having experienced domestic violence, although causality cannot be inferred. Pooled estimates from cross-sectional studies show that women with probable depression in the antenatal and postnatal periods have 3- to 5-fold increased unadjusted odds of having experienced domestic violence over the adulthood lifetime, during the past year, and during pregnancy, with correspondingly high prevalence estimates. Meta-analysis of data from longitudinal studies suggests that women who experience domestic violence during pregnancy have 3-fold increased unadjusted odds of probable depression in the postnatal period. The pooled PAF of 12.7% (95% CI 11.8%–13.6%) calculated from these studies suggests that, if the association between domestic violence during pregnancy and postnatal depression are causal, experiences of domestic violence during pregnancy may contribute to the burden of postnatal mental disorder, and underlines the importance of domestic violence as a public health problem. Individual longitudinal studies also suggest that women with probable depression in the antenatal period have 3- to 5-fold increased odds of experiencing domestic violence during or up to a year after pregnancy. Although causality cannot be inferred, these findings suggest that a two-way association between experiences of domestic violence and probable depression in the antenatal and postnatal periods is likely, in which symptoms of depression may increase women's vulnerability to domestic violence, and having experienced domestic violence can increase the odds of probable depression in the antenatal and postnatal period. Insufficient data were available for other perinatal mental disorders to draw conclusions about the direction of causality for associations. To our knowledge, this systematic review is the first to search for studies reporting on the prevalence and odds of having experienced domestic violence across the full range of antenatal and postnatal mental disorders. There are fewer studies on domestic violence and probable anxiety disorders than depression, but the review found, for the first time, consistent evidence of a high prevalence and increased odds of having experienced domestic violence among women with anxiety and PTSD in the antenatal and postnatal periods. We did not find any studies reporting the relationship between having experienced domestic violence and eating disorders or psychotic disorders, including puerperal psychosis, despite studies outside the perinatal period reporting an increased odds of having experienced domestic violence in women with eating disorders [14], and anecdotal reports of domestic violence associated with puerperal psychosis [104]. Further research is clearly needed for these diagnostic categories. Most studies were carried out in high-income settings; findings were similar in low-income settings, but one study also reported that the odds of psychological distress associated with having experienced domestic violence was higher if the baby was a girl rather than a boy [86]. Risks are therefore likely to be modified by the cultural context of the pregnancy and postpartum period; this may be particularly the case where parents or parents-in-law play a major role in the postpartum period [22]. Strengths and Limitations Strengths of this review include restricting primary studies to those that used diagnostic instruments or validated screening instruments with their recommended cutoff scores to assess mental disorders. The comprehensive search strategy over multiple databases enabled the identification and synthesis of a large number of studies of several diagnostic categories, including depression, anxiety disorders, and PTSD. The review highlights critical gaps in the literature, including few longitudinal studies, few studies reporting on violence perpetrated by family members, and no studies investigating the possible relationship between domestic violence and puerperal psychosis. There was high heterogeneity in pooled estimates of the association between having experienced past-year intimate partner violence and probable depression in both the antenatal and postnatal periods among cross-sectional studies, and there were insufficient studies to analyse the reasons for the higher heterogeneity using meta-regression. Visual inspection of the data, however, suggests that heterogeneity may be due to variation in the timing of recruitment, e.g., for women recruited in the last trimester, proportionally more of the “past year” reference period includes the time they were pregnant than for women recruited in the first trimester. Similarly, proportionally more of the “past year” reference period includes the period of pregnancy for women recruited in the early postpartum period than women recruited at 9–12 mo postpartum. This variation could be relevant because the prevalence of domestic violence can be lower during pregnancy [16],[17] and because the association between domestic violence and depression may vary as a function of when the violence occurred. Insufficient characterisation of participants in the primary studies meant we were unable to assess the role of individual risk factors, such as social class. The lack of consistency in the type of data collected by the primary studies meant we were also unable to adjust estimates for potential confounders (e.g., history of depression or childhood abuse). In addition, most of the longitudinal studies did not provide data on baseline levels of symptoms or domestic violence, preventing clear interpretation on incident depression after domestic violence and vice versa. Thus, although having experienced domestic violence was strongly and consistently associated with probable antenatal and postnatal depression in both longitudinal and cross-sectional studies, we cannot draw firm conclusions about whether the observed association between domestic violence and probable perinatal depression is causal. As the calculation of the pooled PAF (the proportion of probable mental disorder potentially ascribable to exposure to intimate partner violence) is based on an assumption of causality, the PAF estimate should be treated with particular caution. Further high-quality longitudinal studies, including linked database studies, should be conducted to explore the nature of the association between domestic violence and perinatal mental disorder. Future research should also collect and report data on all types of violence (i.e., physical, sexual, and psychological violence); the majority (48/67) of the studies included in this review reported on physical violence—either alone or in combination with other forms of violence—and fewer than half reported prevalence and ORs disaggregated by type of violence. Implications Domestic violence during pregnancy is associated with risks to the fetus, child, and mother [18]–[22]. Our finding that women with high levels of symptoms of a range of perinatal mental disorders have a high prevalence and increased odds of having experienced domestic violence both over the lifetime and during pregnancy highlights the importance of health professionals identifying and responding to domestic violence among women attending antenatal and mental health services. The World Health Organization and some international guidelines recommend identification of domestic violence and mental disorders in women attending antenatal care and mental health care [105]–[107]. However, a recent Cochrane review found little data on whether screening and other interventions improve outcomes for women experiencing domestic violence in the perinatal period [108]. Further data is therefore needed on how maternity and mental health services should best identify women with a history or current experience of domestic violence, respond appropriately and safely, and thus improve health outcomes for women and their infants in the perinatal period. Supporting Information Figure S1 Funnel plots to assess publication bias. (DOC) Click here for additional data file. Table S1 Characteristics and reported outcomes of cross-sectional analyses of included studies. (DOCX) Click here for additional data file. Table S2 Characteristics and reported outcomes of longitudinal analyses of included studies. (DOCX) Click here for additional data file. Text S1 PRISMA checklist of items to include when reporting a systematic review or meta-analysis. (DOC) Click here for additional data file. Text S2 Systematic review protocol. (DOC) Click here for additional data file. Text S3 Search terms for Medline, Embase, and PsycINFO. (DOC) Click here for additional data file. Text S4 Critical appraisal checklist for included studies. (DOC) Click here for additional data file.
- Record: found
- Abstract: found
- Article: not found
Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategies.
Although non-adherence is common across all branches of medicine, psychotic disorders pose additional challenges that increase its risk. Despite the importance of non-adherence, clinicians generally spend too little time on assessing and addressing adherence attitudes and behaviors. Importantly, how adherence is measured significantly impacts the findings, and the most frequently employed methods of asking patients or judging adherence indirectly based on efficacy or tolerability information have poor validity. Novel technologies are being developed that directly assess adherence and that can also be used to both provide real-time feedback to clinicians and serve as an intervention with patients. Several treatments are available that can positively impact adherence. Among psychosocial interventions, those combining multiple approaches and involving multiple domains seem to be most effective. Although long-acting injectable antipsychotics are theoretically a very powerful tool to assure adherence and signal non-adherence, recent results from randomized controlled trials failed to show superiority compared to oral antipsychotics. These data are in contrast to nationwide cohort studies and mirror-image studies, which arguably include more representative patients receiving long-acting antipsychotics in clinical practice. This disconnect suggests that traditional randomized controlled trials are not necessarily the best way to study interventions that are thought to work via reducing non-adherence. Clearly, non-adherence is likely to remain a major public health problem despite treatment advances. However, increasing knowledge about factors affecting adherence and leveraging novel technologies can enhance its early assessment and adequate management, particularly in patients with psychotic disorders.
Author and article information
Contributors
Blanca Fernández-Abascal
Maria Recio-Barbero:
ORCID: https://orcid.org/0000-0003-1783-5453
Margarita Sáenz-Herrero
Rafael Segarra:
ORCID: https://orcid.org/0000-0002-2033-8151
Journal
Journal ID (nlm-ta): Ther Adv Psychopharmacol
Journal ID (iso-abbrev): Ther Adv Psychopharmacol
Journal ID (publisher-id): TPP
Journal ID (hwp): sptpp
Title:
Therapeutic Advances in Psychopharmacology
Publisher:
SAGE Publications
(Sage UK: London, England
)
ISSN
(Print):
2045-1253
ISSN
(Electronic):
2045-1261
Publication date
(Electronic):
31
January
2021
Publication date Collection: 2021
Volume: 11
Electronic Location Identifier: 2045125321991277
Affiliations
[1-2045125321991277]Department of Psychiatry, Marqués de Valdecilla Hospital, Santander, Cantabria, Spain
[2-2045125321991277]Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo,
Spain
[3-2045125321991277]Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo,
Spain
[5-2045125321991277]Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain
[7-2045125321991277]Department of Psychiatry, Cruces University Hospital. Plaza de Cruces S/N. Barakaldo,
Biscay 48903, Spain
[8-2045125321991277]Biocruces Bizkaia Health Research Institute. Cruces University Hospital, Barakaldo,
Spain
Author notes
Author information
Maria Recio-Barbero
https://orcid.org/0000-0003-1783-5453
Rafael Segarra
https://orcid.org/0000-0002-2033-8151
Article
Publisher ID: 10.1177_2045125321991277DOI: 10.1177/2045125321991277
PMC ID: 8851104
PubMed ID: 35186259
SO-VID: 78cd3e23-80a6-43b6-b9c6-9a6c1ecc04a8
Copyright © © The Author(s), 2021
License:
This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).
History
Date
received
: 2
November
2020
Date
accepted
: 10
January
2021
Categories
Subject:
Case Series
Custom metadata
cover-date January-December 2021
typesetter ts1
Data availability: