The activity of the pyrrole insecticide chlorfenapyr in mosquito bioassay: towards a more rational testing and screening of non-neurotoxic insecticides for malaria vector control.

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Abstract

The rapid selection of pyrethroid resistance throughout sub-Saharan Africa is a serious threat to malaria vector control. Chlorfenapyr is a pyrrole insecticide which shows no cross resistance to insecticide classes normally used for vector control and is effective on mosquito nets under experimental hut conditions. Unlike neurotoxic insecticides, chlorfenapyr owes its toxicity to disruption of metabolic pathways in mitochondria that enable cellular respiration. A series of experiments explored whether standard World Health Organization (WHO) guidelines for evaluation of long-lasting insecticidal nets, developed through testing of pyrethroid insecticides, are suitable for evaluation of non-neurotoxic insecticides.

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Journal

Journal ID (iso-abbrev): Malar J

Title: Malaria journal

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1475-2875

ISSN (Print): 1475-2875

Publication date (Electronic): Mar 24 2015

Volume: 14

Affiliations

[1 ] Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. oxandbull@hotmail.com.

[2 ] Department of Entomology and Parasitology, Kilimanjaro Christian Medical University College, Moshi, Kilimanjaro, Tanzania. oxandbull@hotmail.com.

[3 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. oxandbull@hotmail.com.

[4 ] Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. raphael.n'guessan@lshtm.ac.uk.

[5 ] CREC laboratories, Centre de Recherche Entomologique de Cotonou, Laboratoire Nationale, Ministère de la Santé, Cotonou 06, BP 2604, Benin. raphael.n'guessan@lshtm.ac.uk.

[6 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. raphael.n'guessan@lshtm.ac.uk.

[7 ] Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. Rebecca.Jones@lshtm.ac.uk.

[8 ] Department of Entomology and Parasitology, Kilimanjaro Christian Medical University College, Moshi, Kilimanjaro, Tanzania. jvnkit@gmail.com.

[9 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. jvnkit@gmail.com.

[10 ] Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. corine.ngufor@lshtm.ac.uk.

[11 ] CREC laboratories, Centre de Recherche Entomologique de Cotonou, Laboratoire Nationale, Ministère de la Santé, Cotonou 06, BP 2604, Benin. corine.ngufor@lshtm.ac.uk.

[12 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. corine.ngufor@lshtm.ac.uk.

[13 ] Innovative Vector Control Consortium (IVCC), Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. david.malone@liverpool.ac.uk.

[14 ] Department of Entomology and Parasitology, Kilimanjaro Christian Medical University College, Moshi, Kilimanjaro, Tanzania. fwmosha@gmail.com.

[15 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. fwmosha@gmail.com.

[16 ] Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK. mark.rowland@lshtm.ac.uk.

[17 ] Pan-African Malaria Vector Research Consortium, (PAMVERC), Moshi, Tanzania. mark.rowland@lshtm.ac.uk.

Article

Publisher Item ID: 10.1186/s12936-015-0639-x

DOI: 10.1186/s12936-015-0639-x

PMC ID: 4390098

PubMed ID: 25879231

SO-VID: 79857c9e-0a1d-4178-95de-4703f4bdad06

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