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      Haptoglobin: basic and clinical aspects.

      Antioxidants & Redox Signaling

      metabolism, Antioxidants, therapeutic use, Diabetes Mellitus, drug therapy, genetics, Genetic Predisposition to Disease, Genotype, Haptoglobins, physiology, Hemoglobins, Humans, Oxidative Stress, Vascular Diseases, Animals

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          Abstract

          Haptoglobin is an abundant hemoglobin-binding protein present in the plasma. The function of haptoglobin is primarily to determine the fate of hemoglobin released from red blood cells after either intravascular or extravascular hemolysis. There are two common alleles at the Hp genetic locus denoted 1 and 2. There are functional differences between the Hp 1 and Hp 2 protein products in protecting against hemoglobin-driven oxidative stress that appear to have important clinical significance. In particular, individuals with the Hp 2-2 genotype and diabetes mellitus appear to be at significantly higher risk of microvascular and macrovascular complications. A pharmacogenomic strategy of administering high dose antioxidants specifically to Hp 2-2 DM individuals may be clinically effective.

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          Author and article information

          Journal
          19659435
          10.1089/ars.2009.2793

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