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      Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

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          Abstract

          Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV‐protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal‐chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal‐induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB‐induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development.

          Abstract

          The mangrove‐derived Streptomyces bacteria known as MUM273b has been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants

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          Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species.

          Ok-Sun Kim, Yong-Joon Cho, Kihyun Lee … (2012)
          Despite recent advances in commercially optimized identification systems, bacterial identification remains a challenging task in many routine microbiological laboratories, especially in situations where taxonomically novel isolates are involved. The 16S rRNA gene has been used extensively for this task when coupled with a well-curated database, such as EzTaxon, containing sequences of type strains of prokaryotic species with validly published names. Although the EzTaxon database has been widely used for routine identification of prokaryotic isolates, sequences from uncultured prokaryotes have not been considered. Here, the next generation database, named EzTaxon-e, is formally introduced. This new database covers not only species within the formal nomenclatural system but also phylotypes that may represent species in nature. In addition to an identification function based on Basic Local Alignment Search Tool (blast) searches and pairwise global sequence alignments, a new objective method of assessing the degree of completeness in sequencing is proposed. All sequences that are held in the EzTaxon-e database have been subjected to phylogenetic analysis and this has resulted in a complete hierarchical classification system. It is concluded that the EzTaxon-e database provides a useful taxonomic backbone for the identification of cultured and uncultured prokaryotes and offers a valuable means of communication among microbiologists who routinely encounter taxonomically novel isolates. The database and its analytical functions can be found at http://eztaxon-e.ezbiocloud.net/.
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            Mangrove forests: Resilience, protection from tsunamis, and responses to global climate change

            Daniel Alongi (2008)
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              Counting on natural products for drug design.

              Tiago Rodrigues, Daniel Reker, Petra Schneider … (2016)
              Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.
              Article 0 comments Cited 285 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Kok‐Gan Chan: kokgan@um.edu.my
                Learn‐Han Lee: lee.learn.han@monash.edu , leelearnhan@yahoo.com
                Bey‐Hing Goh:
                ORCID: https://orcid.org/0000-0003-1006-3649
                goh.bey.hing@monash.edu
                Journal
                Journal ID (nlm-ta): Microbiologyopen
                Journal ID (iso-abbrev): Microbiologyopen
                Journal ID (doi): 10.1002/(ISSN)2045-8827
                Journal ID (publisher-id): MBO3
                Title: MicrobiologyOpen
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2045-8827
                Publication date (Electronic): 14 June 2019
                Publication date Collection: October 2019
                Volume: 8
                Issue: 10 ( doiID: 10.1002/mbo3.v8.10 )
                Electronic Location Identifier: e859
                Affiliations
                [ 1 ] Novel Bacteria and Drug Discovery Research Group Microbiome and Bioresource Research Strength Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia Bandar Sunway Selangor Darul Ehsan Malaysia
                [ 2 ] Biofunctional Molecule Exploratory (BMEX) Research Group School of Pharmacy Monash University Malaysia Bandar Sunway Selangor Darul Ehsan Malaysia
                [ 3 ] Institute of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou PR China
                [ 4 ] Department of Biological Sciences, School of Science and Technology Sunway University Bandar Sunway Selangor Malaysia
                [ 5 ] International Genome Centre Jiangsu University Zhenjiang China
                [ 6 ] Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science University of Malaya Kuala Lumpur Malaysia
                [ 7 ] The Institute of Pharmaceutical Sciences University of Veterinary and Animal Sciences Lahore Pakistan
                Author notes
                [*] [* ] Correspondence

                Kok‐Gan Chan, University Malaya, 50603, Kuala Lumpur, Malaysia.

                Email: kokgan@ 123456um.edu.my

                Learn‐Han Lee and Bey‐Hing Goh, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.

                Email: lee.learn.han@ 123456monash.edu ; leelearnhan@ 123456yahoo.com (L. ‐H. L.) and goh.bey.hing@ 123456monash.edu (B. ‐H. G.)

                Author information
                https://orcid.org/0000-0003-1006-3649
                Article
                Publisher ID: MBO3859
                DOI: 10.1002/mbo3.859
                PMC ID: 6813444
                PubMed ID: 31199601
                SO-VID: 7a7eae7b-95e7-4ee2-9fd4-b47db695251f
                Copyright © © 2019 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 06 June 2018
                Date revision received : 13 April 2019
                Date accepted : 17 April 2019
                Page count
                Figures: 5, Tables: 4, Pages: 16, Words: 11866
                Funding
                Funded by: MOSTI eScienceFund Grant , open-funder-registry 10.13039/501100003200;
                Award ID: 02-02-10-SF0215
                Funded by: University Malaya Research Grant
                Award ID: JBK grant GA002-2016
                Funded by: University Malaya Research Grant
                Award ID: PPP grants PG088-2015B & PG089-2015B
                Funded by: Biotek Abadi Sdn Bhd
                Award ID: GBA-81811A
                Categories
                Subject: Original Article
                Subject: Original Articles
                Custom metadata
                source-schema-version-number 2.0
                cover-date October 2019
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.0 mode:remove_FC converted:25.10.2019

                ScienceOpen disciplines: Microbiology & Virology
                Keywords: antioxidant,cosmeceutical,mangrove,streptomyces,uv‐protective
                Data availability:
                ScienceOpen disciplines: Microbiology & Virology
                Keywords: antioxidant, cosmeceutical, mangrove, streptomyces, uv‐protective

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