Elevated levels of circulating histones indicate disease activity in patients with hand, foot, and mouth disease (HFMD).

Abstract

Hand, foot, and mouth disease (HFMD) is a common infectious disease in children, characterized by acute viral infection accompanying acute inflammatory responses. Circulating histones are leading mediators of the inflammatory processes. This study aimed to elucidate whether circulating histones play a contributory role during HFMD.