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Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells.
Dongrui Ma
1 ,
Heming Wei ,
Yongxing Zhao ,
Jun Lu ,
Guang Li ,
Norliza Binte Esmail Sahib ,
Teng Hong Tan ,
Keng Yean Wong ,
Winston Shim ,
Philip Wong ,
Stuart A Cook ,
Reginald Liew
Oct 15 2013
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Abstract
Type 3 long QT syndrome (LQT3) is the third most common form of LQT syndrome and is characterized by QT-interval prolongation resulting from a gain-of-function mutation in SCN5A. We aimed to establish a patient-specific human induced pluripotent stem cell (hiPSC) model of LQT3, which could be used for future drug testing and development of novel treatments for this inherited disorder.