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Effects of short-term antiretroviral therapy on blood routine, liver and kidney function between HIV patients’ interval from diagnosis to ART
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Abstract
Objective To understand the risk factors of HIV patients’ interval from diagnosis to ART, and to explore the effects on blood routine, liver and kidney function after short-term antiretroviral therapy (ART).
Methods The medical record information of HIV patients receiving ART in Haikou were collected from 2017 to 2021, and the interval from diagnosis to ART was divided into 4 groups: ≤30 days, >30–60 days, >60–365 days and >365 days. The differences of blood routine, liver and kidney function after one month therapy were compared between different groups.
Results Among the 302 subjects, 91.7% were male of all, 71.8% subjects had accepted ART within 60 days after diagnosis. At the time of diagnosis, 6.8% had hepatitis B and 3.6% had tuberculosis. Analysis of influencing factors showed that only gender and time of diagnosis had significant differences ( P < 0.05). The baseline of content of hemoglobin and total protein had difference among four groups, >30–60 days group was lowest among four groups. After one month of ART, there was no difference in blood routine indexes among all groups ( P > 0.05). The liver and kidney function showed that total albumin content increased in all groups (0.02 U/L, 1.91 U/L, 3.67 U/L and 2.62 U/L, respectively), with statistical significance ( P < 0.05).
Conclusion The risk factors of interval from diagnosis to ART were gender and time of diagnosis, and total albumin were influenced by interval.
Abstract
摘要： 目的 了解HIV感染者从确诊到接受抗病毒治疗 (antiretroviral therapy, ART) 间隔的影响因素, 探讨不同间 隔对短期治疗后血常规及肝肾功能的影响。 方法 收集海口市2017—2021年接受ART的HIV感染者的病案信息, 将 感染者从确诊到接受ART的间隔分为≤30 d、>30~60 d、>60~365 d和>365 d 4组, 比较不同组间ART 1个月后血常规和 肝肾功能的差异。 结果 在302例病例中, 男性91.7%, 确诊60 d内进行ART者为71.8%;确诊时6.8%的人合并乙肝, 3.6%的人感染过肺结核。影响因素分析发现, 各组仅在性别和确诊时间上有统计学差异 ( P < 0.05)。各组的基线平均 红细胞血红蛋白含量和总蛋白差异有统计学意义 ( P < 0.05), 均是>30〜60 d组含量低于其他组。治疗1个月后, 各组血 常规的各项指标变化差异无统计学意义 ( P > 0.05); 在肝肾功能方面, 各组白蛋白含量均有增加, 分别是0.02 U/L、1.91 U/L、3.67U/L和2.62 U/L, 各组间差异有统计学意义 ( P < 0.05)。 结论 性别和确诊时间是影响确诊到ART间隔的 因素, 时间间隔对白蛋白含量有影响。