Nonsuicidal self-injury among youth and young adults remains a challenging behavior for clinicians to treat. Etiological models of self-injury have laid a foundation for the development of effective treatments that focus on the intrapersonal and interpersonal regulating functions of the behavior but have failed to consider other mechanisms that may facilitate the initiation and maintenance of the self-injury. This article presents a theoretical argument that body disregard is a necessary factor to include in etiological conceptualizations of nonsuicidal self-injurious behavior as well as within treatment approaches. Empirical literature is reviewed to provide a solid basis for the tenant that body disregard facilitates self-injury. Suggestions for incorporating treatment strategies that address body-related factors are offered along with some directions for future research.