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      Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

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          Abstract

          The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on the management of type 2 diabetes in adults. A systematic evaluation of the literature since 2014 informed new recommendations. These include additional focus on lifestyle management and diabetes self-management education and support. For those with obesity, efforts targeting weight loss, including lifestyle, medication, and surgical interventions, are recommended. With regards to medication management, for patients with clinical cardiovascular disease, a sodium–glucose cotransporter 2 (SGLT2) inhibitor or a glucagon-like peptide 1 (GLP-1) receptor agonist with proven cardiovascular benefit is recommended. For patients with chronic kidney disease or clinical heart failure and atherosclerotic cardiovascular disease, an SGLT2 inhibitor with proven benefit is recommended. GLP-1 receptor agonists are generally recommended as the first injectable medication.

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          Most cited references156

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          2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society.

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            Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

            The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.
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              Thiazolidinediones

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                Author and article information

                Journal
                Diabetes Care
                Diabetes Care
                diacare
                dcare
                Diabetes Care
                Diabetes Care
                American Diabetes Association
                0149-5992
                1935-5548
                December 2018
                5 October 2018
                : 41
                : 12
                : 2669-2701
                Affiliations
                [1] 1Diabetes Research Centre, University of Leicester, Leicester, U.K.
                [2] 2Leicester Diabetes Centre, Leicester General Hospital, Leicester, U.K.
                [3] 3Department of Medicine, Duke University School of Medicine, Durham, NC
                [4] 4National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD
                [5] 5Department of Medicine, Yale School of Medicine, New Haven, CT
                [6] 6Clinical and Experimental Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium
                [7] 7Department of Internal Medicine, Catholic University, Rome, Italy
                [8] 8Diabetes and Nutritional Sciences, King’s College London, London, U.K.
                [9] 9Steno Diabetes Center Copenhagen, Gentofte, Denmark
                [10] 10University of Copenhagen, Copenhagen, Denmark
                [11] 11Second Medical Department, Aristotle University Thessaloniki, Thessaloniki, Greece
                [12] 12Department of Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA
                [13] 13Harvard Medical School, Boston, MA
                [14] 14Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC
                Author notes
                Corresponding author: John B. Buse, jbuse@ 123456med.unc.edu .
                Author information
                http://orcid.org/0000-0002-6099-2406
                http://orcid.org/0000-0003-2021-528X
                http://orcid.org/0000-0003-0221-4072
                http://orcid.org/0000-0002-9723-3876
                Article
                0033
                10.2337/dci18-0033
                6245208
                30291106
                7ddb74a8-72d3-4e87-8278-196734b4a4dd
                © 2018 American Diabetes Association and European Association for the Study of Diabetes.

                Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

                History
                Page count
                Pages: 33
                Categories
                Consensus Report

                Endocrinology & Diabetes
                Endocrinology & Diabetes

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