Hypolipidemic effect of dihydroisoquinoline oxaziridine in high-fat diet-fed rats.

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Abstract

Obesity is a serious health problem that increases the risk of many complications, including diabetes and cardiovascular disease. This study aims to evaluate, for the first time, the effects of oxaziridine 3 on lipoprotein lipase activity in the serum of rats fed with a high-fat diet (HFD) on body weight, lipid profile and liver-kidney functions. The administration of oxaziridine 3 to HFD-rats lowered body weight and inhibited the lipase activity of obese rats leading to notable decrease of T-Ch, TGs and LDL-Ch levels accompanied with an increase in HDL-Ch concentration in serum. Moreover, the findings of this study revealed that oxaziridine 3 helped to protect liver tissue from the appearance of fatty cysts. Additionally, oxaziridine 3 administration to HFD-rats induces antioxidant activity proven by the increase of superoxide dismutase (SOD) and catalase (CAT) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels. It also induces the protection of liver-kidney functions confirmed by a decrease in the levels of toxicity parameters in blood.

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Author and article information

Journal

Journal ID (iso-abbrev): Biomed. Pharmacother.

Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Publisher: Elsevier BV

ISSN (Electronic): 1950-6007

ISSN (Print): 0753-3322

Publication date (Electronic): Aug 2016

Volume: 82

Affiliations

[1 ] Laboratory of Chemistry of Natural Products, Faculty of Sciences, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.

[2 ] Laboratory of plant biotechnology applied to crop improvement, Faculty of Sciences, University of Sfax, 802, 3018 Sfax, Tunisia.

[3 ] Biochemistry Laboratory, CHU Hédi Chaker, Sfax 3000, Tunisia.

[4 ] Pharmacology Laboratory, Faculty of Medicine, University of Sfax, 3000 Sfax, Tunisia.

[5 ] Laboratory of Animal Ecophysiology, Faculty of Sciences, University of Sfax, P.O. box 802, 3018 Sfax, Tunisia.

[6 ] Laboratory of Biomass Valorization and Proteins Production in Eukaryotes, Center of Biotechnology of Sfax, University of Sfax, PB" 1177", 3038 Sfax, Tunisia.

[7 ] Laboratory of Chemistry of Natural Products, Faculty of Sciences, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia. Electronic address: majed_kammoun@yahoo.fr.

Article

Publisher Item ID: S0753-3322(16)30452-8

DOI: 10.1016/j.biopha.2016.06.003

PubMed ID: 27470409

SO-VID: 7f15711a-c263-46ee-bc52-7ffed6f27ef3

History

Keywords: Liver-kidney functions,Obesity,Oxaziridine

Data availability:

Keywords: Liver-kidney functions, Obesity, Oxaziridine

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