Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

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Abstract

Outcomes in primary biliary cirrhosis (PBC) can be predicted by biochemical response to ursodeoxycholic acid (UDCA). Such stratification inadequately captures cirrhosis/portal hypertension, recognised factors associated with adverse events.

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Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Jun 2014

Volume: 60

Issue: 6

Affiliations

[1 ] National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) and Centre for Liver Research, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

[2 ] National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) and Centre for Liver Research, University of Birmingham, Birmingham, UK; Department of Internal Medicine IV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich Schiller University Jena, Germany.

[3 ] Toronto Center for Liver Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

[4 ] Department of Internal Medicine IV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.

[5 ] Toronto Center for Liver Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Gastroenterology and Metabology, Ehime University, Graduate School of Medicine, Shitsukawa To-on, Ehime, Japan.

[6 ] Toronto Center for Liver Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Royal Hospital, Sultanate of Oman, Oman.

[7 ] Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

[8 ] Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK; Organ Donation and Transplant, NHS Blood and Transplant, Bristol, UK.

[9 ] Toronto Center for Liver Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Division of Gastroenterology & Hepatology, Erasmus MC University Hospital, Rotterdam, The Netherlands.

[10 ] National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) and Centre for Liver Research, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. Electronic address: g.hirschfield@bham.ac.uk.

Article

Publisher Item ID: S0168-8278(14)00105-6

DOI: 10.1016/j.jhep.2014.01.029

PubMed ID: 24548531

SO-VID: 80f3768c-2fef-47df-b275-37d34dac40e1

History

Keywords: Autoimmune liver disease,Survival,Ursodeoxycholic acid,Outcome prediction,Liver transplantation,Cholestasis

Data availability:

Keywords: Autoimmune liver disease, Survival, Ursodeoxycholic acid, Outcome prediction, Liver transplantation, Cholestasis

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

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