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Effect of the native polysaccharide of cashew-nut tree gum exudate on murine peritoneal macrophage modulatory activities
F.T. Yamassaki ,
R.M. Lenzi ,
L.H. Campestrini ,
F. Bovo ,
M. Seyfried ,
A. Soldera-Silva ,
F.R. Stevan-Hancke ,
S.F. Zawadzki-Baggio ,
F.A. Pettolino ,
A. Bacic ,
J.B.B. Maurer
July 2015
July 2015
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Abstract
The native polysaccharide of cashew-nut tree gum exudate (CNTG) and its arabinogalactan-protein
component (CNTG-AGP) were tested by using immuno-stimulant and anti-inflammatory in
vitro assays of murine peritoneal macrophage activities. In the assay for immuno-stimulant
activity (without previous treatment with lipopolysaccharide; LPS), CNTG increased
the production of interleukin (IL)-10 and both CNTG and CNTG-AGP decreased the concentrations
of IL6. When the macrophages were incubated in the presence of LPS and CNTG a decrease
in the levels of nitric oxide (NO(·)) and IFN-γ was observed. The results could explain
the popular use of CNTG as an anti-inflammatory. In addition, CNTG is the main component
of the cashew-nut tree gum exudate, which has been considered a versatile polymer
with potential pharmaceutical and food industry applications. These data may contribute
to the study of the immunomodulation activity of plant polysaccharides, as well as
encourage future experiments in the field of cashew-nut tree gum exudate applications.