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      Matrix metalloproteinases: regulators of the tumor microenvironment.

      1 , ,
      Cell
      Elsevier BV

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          Abstract

          Extracellular proteolysis mediates tissue homeostasis. In cancer, altered proteolysis leads to unregulated tumor growth, tissue remodeling, inflammation, tissue invasion, and metastasis. The matrix metalloproteinases (MMPs) represent the most prominent family of proteinases associated with tumorigenesis. Recent technological developments have markedly advanced our understanding of MMPs as modulators of the tumor microenvironment. In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner. These aspects of MMP function are reorienting our approaches to cancer therapy.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Apr 02 2010
          : 141
          : 1
          Affiliations
          [1 ] Department of Anatomy and Biomedical Sciences Program, University of California, San Francisco, CA 94143-0452, USA.
          Article
          S0092-8674(10)00288-6 NIHMS196774
          10.1016/j.cell.2010.03.015
          2862057
          20371345
          854e3f1b-860d-4bf7-826e-217b02d1ab90
          Copyright 2010 Elsevier Inc. All rights reserved.
          History

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