Dual Therapy With Darunavir and Ritonavir Plus Lamivudine vs Triple Therapy With Darunavir and Ritonavir Plus Tenofovir Disoproxil Fumarate and Emtricitabine or Abacavir and Lamivudine for Maintenance of Human Immunodeficiency Virus Type 1 Viral Suppression: Randomized, Open-Label, Noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial.

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Abstract

Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-1) suppression.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin. Infect. Dis.

Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6591

ISSN (Print): 1058-4838

Publication date (Electronic): Nov 29 2017

Volume: 65

Issue: 12

Affiliations

[1 ] Hospital Universitario Doce de Octubre, imas12, UCM, Madrid.

[2 ] Hospital Universitari Vall d'Hebron, Barcelona.

[3 ] Hospital La Paz, IdiPAZ, Madrid.

[4 ] Hospital Clínico Universitario Virgen de la Victoria, IBIMA, Málaga.

[5 ] Hospital Universitario Donostia, Instituto de Investigación BioDonostia, San Sebastian.

[6 ] Hospital Son Llatzer, Palma de Mallorca.

[7 ] Hospital Santa Creu i Sant Pau, Barcelona.

[8 ] Hospital Príncipe de Asturias.

[9 ] Hospital Universitario Severo Ochoa, Madrid.

[10 ] Hospital Infanta Elena, Huelva.

[11 ] Hospital Clínico.

[12 ] Hospital Universitario Infanta Leonor, Madrid.

[13 ] Hospital de Mataró.

[14 ] Hospital del Mar, Barcelona.

[15 ] Hospital Universitario Reina Sofía, IMIBIC, Córdoba.

[16 ] Centro Nacional de Epidemiología.

[17 ] Fundación SEIMC-Gesida, Madrid, Spain.

Article

Publisher Item ID: 4083646

DOI: 10.1093/cid/cix734

PubMed ID: 29020293

SO-VID: 864a2fd3-fdf0-4246-bf5d-ca4b9352aa90

History

Keywords: switch,darunavir/ritonavir,dual therapy,lamivudine

Data availability:

Keywords: switch, darunavir/ritonavir, dual therapy, lamivudine

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