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      Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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          Abstract

          Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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          Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources

          Natural antioxidants are widely distributed in food and medicinal plants. These natural antioxidants, especially polyphenols and carotenoids, exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis and anticancer. The effective extraction and proper assessment of antioxidants from food and medicinal plants are crucial to explore the potential antioxidant sources and promote the application in functional foods, pharmaceuticals and food additives. The present paper provides comprehensive information on the green extraction technologies of natural antioxidants, assessment of antioxidant activity at chemical and cellular based levels and their main resources from food and medicinal plants.
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            A Review on Kombucha Tea-Microbiology, Composition, Fermentation, Beneficial Effects, Toxicity, and Tea Fungus

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              Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review.

              Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea. EGCG is mainly absorbed in the intestine, and gut microbiota play a critical role in its metabolism prior to absorption. EGCG exhibits versatile bioactivities, with its anti-cancer effect most attracting due to the cancer preventive effect of green tea consumption, and a great number of studies intensively investigated its anti-cancer effect. In this review, we therefore, first stated the absorption and metabolism process of EGCG, and then summarized its anti-cancer effect in vitro and in vivo, including its manifold anti-cancer actions and mechanisms, especially its anti-cancer stem cell effect, and next highlighted its various molecular targets involved in cancer inhibition. Finally, the anti-cancer effect of EGCG analogs and nanoparticles, as well as the potential cancer promoting effect of EGCG were also discussed. Understanding of the absorption, metabolism, anti-cancer effect and molecular targets of EGCG can be of importance to better utilize it as a chemopreventive and chemotherapeutic agent.
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                Author and article information

                Journal
                Int J Mol Sci
                Int J Mol Sci
                ijms
                International Journal of Molecular Sciences
                MDPI
                1422-0067
                08 December 2019
                December 2019
                : 20
                : 24
                : 6196
                Affiliations
                [1 ]Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; tanggy5@ 123456mail2.sysu.edu.cn (G.-Y.T.); mengx7@ 123456mail2.sysu.edu.cn (X.M.); zhaocn@ 123456mail2.sysu.edu.cn (C.-N.Z.); liuq248@ 123456mail2.sysu.edu.cn (Q.L.)
                [2 ]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, No. 10 Sassoon Road, Pokfulam, Hong Kong 999077, China; yfeng@ 123456hku.hk (Y.-B.F.); lishaha@ 123456hku.hk (S.L.)
                [3 ]Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; weixinlin@ 123456sjtu.edu.cn (X.-L.W.); hcorke@ 123456sjtu.edu.cn (H.C.)
                [4 ]Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610213, China
                [5 ]The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, 05-552 Magdalenka, Poland; atanas.atanasov@ 123456univie.ac.at
                Author notes
                [* ]Correspondence: ganrenyou@ 123456caas.cn (R.-Y.G.); lihuabin@ 123456mail.sysu.edu.cn (H.-B.L.); Tel.: +86-28-80203191 (R.-Y.G.); +86-20-87332391 (H.-B.L.)
                [†]

                The authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0003-2545-0967
                https://orcid.org/0000-0003-2332-8554
                Article
                ijms-20-06196
                10.3390/ijms20246196
                6941079
                31817990
                88d930c5-65ac-4678-a080-49a1de8a87f6
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 27 October 2019
                : 06 December 2019
                Categories
                Review

                Molecular biology
                tea,camellia sinensis,phytochemicals,catechins,health benefits,bioavailability,safety
                Molecular biology
                tea, camellia sinensis, phytochemicals, catechins, health benefits, bioavailability, safety

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