Association of triglyceride-glucose index with the risk of prostate cancer: a retrospective study

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Prostate cancer is the most common malignancy in men, and its incidence is increasing year by year. Some studies have shown that risk factors for prostate cancer are related to insulin resistance. The triglyceride-glucose (TyG) index is a marker of insulin resistance. We investigated the validity of TyG index for predicting prostate cancer and the dose-response relationship in prostate cancer in relation to it.

Objective

To investigate the risk factors of TyG index and prostate cancer prevalence.

Methods

This study was screened from the First Affiliated Hospital of Xinjiang Medical University and included 767 people, including 136 prostate cancer patients in the case group and 631 healthy people in the control group. The relationship between TyG index and the risk of prostate cancer was analyzed by one-way logistic regression, adjusted for relevant factors, and multi-factor logistic regression analysis was performed to further investigate the risk factors affecting the prevalence of prostate cancer. ROC curves and Restricted Cubic Spline were established to determine the predictive value and dose-response relationship of TyG index in prostate cancer.

Results

Blood potassium (OR = 0.056, 95% CI [0.021–0.148]), total cholesterol (OR = 1.07, 95% CI [0.792–1.444]) and education level (OR = 0.842, 95% CI [0.418–1.697]) were protective factors for prostate cancer, alkaline phosphatase, age, LDL, increased the risk of prostate cancer (OR = 1.016, 95% CI [1.006–1.026]) (OR = 139.253, 95% CI [18.523–1,046.893] (OR = 0.318, 95% CI [0.169–0.596]); TyG index also was a risk factor for prostate cancer, the risk increased with TyG levels,and persons in the TyGQ3 group (8.373–8.854 mg/dL) was 6.918 times (95% CI [2.275–21.043]) higher than in the Q1 group,in the TyGQ4 group (≥8.854) was 28.867 times of those in the Q1 group (95% CI [9.499–87.727]).

Conclusion

TyG index may be a more accurate and efficient predictor of prostate cancer.

Related collections

Most cited references 35

Record: found
Abstract: found
Article: not found

Cancer statistics, 2018

Kimberly D Miller, Rebecca Siegel, Ahmedin Jemal (2018)

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2014, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2015, were collected by the National Center for Health Statistics. In 2018, 1,735,350 new cancer cases and 609,640 cancer deaths are projected to occur in the United States. Over the past decade of data, the cancer incidence rate (2005-2014) was stable in women and declined by approximately 2% annually in men, while the cancer death rate (2006-2015) declined by about 1.5% annually in both men and women. The combined cancer death rate dropped continuously from 1991 to 2015 by a total of 26%, translating to approximately 2,378,600 fewer cancer deaths than would have been expected if death rates had remained at their peak. Of the 10 leading causes of death, only cancer declined from 2014 to 2015. In 2015, the cancer death rate was 14% higher in non-Hispanic blacks (NHBs) than non-Hispanic whites (NHWs) overall (death rate ratio [DRR], 1.14; 95% confidence interval [95% CI], 1.13-1.15), but the racial disparity was much larger for individuals aged <65 years (DRR, 1.31; 95% CI, 1.29-1.32) compared with those aged ≥65 years (DRR, 1.07; 95% CI, 1.06-1.09) and varied substantially by state. For example, the cancer death rate was lower in NHBs than NHWs in Massachusetts for all ages and in New York for individuals aged ≥65 years, whereas for those aged <65 years, it was 3 times higher in NHBs in the District of Columbia (DRR, 2.89; 95% CI, 2.16-3.91) and about 50% higher in Wisconsin (DRR, 1.78; 95% CI, 1.56-2.02), Kansas (DRR, 1.51; 95% CI, 1.25-1.81), Louisiana (DRR, 1.49; 95% CI, 1.38-1.60), Illinois (DRR, 1.48; 95% CI, 1.39-1.57), and California (DRR, 1.45; 95% CI, 1.38-1.54). Larger racial inequalities in young and middle-aged adults probably partly reflect less access to high-quality health care. CA Cancer J Clin 2018;68:7-30. © 2018 American Cancer Society.

0 comments Cited 3402 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.

S. O'Neill, L O'Driscoll (2015)

Obesity is reaching epidemic proportions with recent worldwide figures estimated at 1.4 billion and rising year-on-year. Obesity affects all socioeconomic backgrounds and ethnicities and is a pre-requisite for metabolic syndrome. Metabolic syndrome is a clustering of risk factors, such as central obesity, insulin resistance, dyslipidaemia and hypertension that together culminate in the increased risk of type 2 diabetes mellitus and cardiovascular disease. As these conditions are among the leading causes of deaths worldwide and metabolic syndrome increases the risk of type 2 diabetes mellitus fivefold and cardiovascular disease threefold, it is of critical importance that a precise definition is agreed upon by all interested parties. Also of particular interest is the relationship between metabolic syndrome and cancer. Metabolic syndrome has been associated with a plethora of cancers including breast, pancreatic, colon and liver cancer. Furthermore, each individual risk factor for metabolic syndrome has also an association with cancer. Our review collates internationally generated information on metabolic syndrome, its many definitions and its associations with life-threatening conditions including type 2 diabetes mellitus, cardiovascular disease and cancer, providing a foundation for future advancements on this topic. © 2014 The Authors Obesity Reviews published by John Wiley & Sons Ltd on behalf of International Association for the Study of Obesity (IASO).

0 comments Cited 280 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study.

José Pareja, Marcos Tambascia, S. Novaes … (2011)

The TyG index was evaluated as a surrogate method for estimation of insulin resistance (IR). TyG index correlated with adiposity, metabolic and atherosclerosis markers related to IR and presented a moderate degree of agreement with hyperglycemic clamp. TyG index represents an accessible tool for assessment of IR in clinical practice. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

0 comments Cited 218 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Hengqing An

Ning Tao

Journal

Journal ID (nlm-ta): PeerJ

Journal ID (iso-abbrev): PeerJ

Journal ID (publisher-id): peerj

Title: PeerJ

Publisher: PeerJ Inc. (San Diego, USA )

ISSN (Electronic): 2167-8359

Publication date (Electronic): 7 November 2023

Publication date Collection: 2023

Volume: 11

Electronic Location Identifier: e16313

Affiliations

[1 ]School of Public Health, Xinjiang Medical University , Urumqi, China

[2 ]School of Traditional Chinese Medicine, Xinjiang Medical University , Urumqi, China

[3 ]Department of Urology, The First Affiliated Hospital of Xinjiang Medical University , Urumqi, China

[4 ]Department of Epidemiological Statistics, School of Public Health, Xinjiang Medical University , Urumqi, China

Article

Publisher ID: 16313

DOI: 10.7717/peerj.16313

PMC ID: 10637243

SO-VID: 8a823081-92c7-4660-9c7f-64420422a71d

License:

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

History

Date received : 31 May 2023

Date accepted : 27 September 2023

Funding

Funded by: Key Project of Natural Science Foundation of Xinjiang Uygur Autonomous Region

Award ID: 2022D01D39

Funded by: Xinjiang Uygur Autonomous Region Tianshan Talent Youth Top-notch Project

Award ID: 2022TSYCCX0026

Funded by: Xinjiang Medical University’s 17th College Students’ Innovative Training Program Project

Award ID: S202210760063

This work was supported by the Key Project of Natural Science Foundation of Xinjiang Uygur Autonomous Region (Number: 2022D01D39); the Xinjiang Uygur Autonomous Region Tianshan Talent Youth Top-notch Project (Number: 2022TSYCCX0026); and the Xinjiang Medical University’s 17th College Students’ Innovative Training Program Project (Number: S202210760063). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Association of triglyceride-glucose index with the risk of prostate cancer: a retrospective study

Read this article at

Abstract

Background

Objective

Methods

Results

Conclusion

Related collections

Karger: Nutrition and Dietetics

Most cited references 35

Cancer statistics, 2018

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies.

TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study.

Author and article information

Contributors

Journal

Affiliations

Article

History

Funding

Categories

Comments

Comment on this article

Similar content 303

Most referenced authors 385