Spatial epidemiology and adaptive targeted sampling to manage the Chagas disease vector Triatoma dimidiata

Abstract

Widespread application of insecticide remains the primary form of control for Chagas disease in Central America, despite only temporarily reducing domestic levels of the endemic vector Triatoma dimidiata and having little long-term impact. Recently, an approach emphasizing community feedback and housing improvements has been shown to yield lasting results. However, the additional resources and personnel required by such an intervention likely hinders its widespread adoption. One solution to this problem would be to target only a subset of houses in a community while still eliminating enough infestations to interrupt disease transfer. Here we develop a sequential sampling framework that adapts to information specific to a community as more houses are visited, thereby allowing us to efficiently find homes with domiciliary vectors while minimizing sampling bias. The method fits Bayesian geostatistical models to make spatially informed predictions, while gradually transitioning from prioritizing houses based on prediction uncertainty to targeting houses with a high risk of infestation. A key feature of the method is the use of a single exploration parameter, α, to control the rate of transition between these two design targets. In a simulation study using empirical data from five villages in southeastern Guatemala, we test our method using a range of values for α, and find it can consistently select fewer homes than random sampling, while still bringing the village infestation rate below a given threshold. We further find that when additional socioeconomic information is available, much larger savings are possible, but that meeting the target infestation rate is less consistent, particularly among the less exploratory strategies. Our results suggest new options for implementing long-term T. dimidiata control.

Author summary

Effective public health interventions for the control and elimination of neglected tropical diseases require an efficient use of resources while still causing long-term disease reduction at the community level. To use resources to best effect, areas most in need of control efforts must be identified. However, strategies for correctly identifying these areas are rarely known due to the complex environmental, biological, and cultural factors shaping disease spread. In turn, incorrect prioritization of control targets can cause the intervention to have no lasting effect. We address this tradeoff between efficiency and efficacy by adapting control priorities throughout an intervention, targeting areas of high uncertainty during the initial stages while shifting to areas of greatest risk at later stages. In the context of controlling Triatoma dimidiata, the primary vector of Chagas disease in several countries in Latin America, our methods provide a means of targeting only a subset of homes for insecticide and housing improvements, while still reducing a village’s overall infestation rate below the critical threshold.