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      Detergent-resistant membranes should not be identified with membrane rafts.

      Trends in Biochemical Sciences
      Cell Membrane, chemistry, drug effects, metabolism, Detergents, pharmacology, Lipid Metabolism, Membrane Microdomains, Solubility, Temperature, Thermodynamics

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          Abstract

          Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.

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          Journal
          15996869
          10.1016/j.tibs.2005.06.004

          Chemistry
          Cell Membrane,chemistry,drug effects,metabolism,Detergents,pharmacology,Lipid Metabolism,Membrane Microdomains,Solubility,Temperature,Thermodynamics

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