For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
680
views
211
references
 Top references
cited by
90
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      494
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Implication of haematophagous arthropod salivary proteins in host-vector interactions

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The saliva of haematophagous arthropods contains an array of anti-haemostatic, anti-inflammatory and immunomodulatory molecules that contribute to the success of the blood meal. The saliva of haematophagous arthropods is also involved in the transmission and the establishment of pathogens in the host and in allergic responses. This survey provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins characterised in various haematophagous arthropod species. The potential biological and epidemiological applications of these immunogenic salivary molecules will be discussed with an emphasis on their use as biomarkers of exposure to haematophagous arthropod bites or vaccine candidates that are liable to improve host protection against vector-borne diseases.

          Related collections

          Most cited references211

          • Record: found
          • Abstract: found
          • Article: not found

          The global distribution of clinical episodes of Plasmodium falciparum malaria.

          Robert W. Snow, Carlos Guerra, Abdisalan Noor … (2005)
          Interest in mapping the global distribution of malaria is motivated by a need to define populations at risk for appropriate resource allocation and to provide a robust framework for evaluating its global economic impact. Comparison of older and more recent malaria maps shows how the disease has been geographically restricted, but it remains entrenched in poor areas of the world with climates suitable for transmission. Here we provide an empirical approach to estimating the number of clinical events caused by Plasmodium falciparum worldwide, by using a combination of epidemiological, geographical and demographic data. We estimate that there were 515 (range 300-660) million episodes of clinical P. falciparum malaria in 2002. These global estimates are up to 50% higher than those reported by the World Health Organization (WHO) and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries. Without an informed understanding of the cartography of malaria risk, the global extent of clinical disease caused by P. falciparum will continue to be underestimated.
          Article 0 comments Cited 676 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The genome sequence of the malaria mosquito Anopheles gambiae.

            Robert A Holt, G Mani Subramanian, Aaron Halpern … (2002)
            Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence of two haplotypes of approximately equal frequency ("dual haplotypes") in a substantial fraction of the genome likely reflects the outbred nature of the PEST strain. The sequence produced a conservative inference of more than 400,000 single-nucleotide polymorphisms that showed a markedly bimodal density distribution. Analysis of the genome sequence revealed strong evidence for about 14,000 protein-encoding transcripts. Prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect.
            Article 0 comments Cited 598 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives.

              Jose Ribeiro, Ivo Francischetti (2003)
              This review addresses the problems insects and ticks face to feed on blood and the solutions these invertebrates engender to overcome these obstacles, including a sophisticated salivary cocktail of potent pharmacologic compounds. Recent advances in transcriptome and proteome research allow an unprecedented insight into the complexity of these compounds, indicating that their molecular diversity as well as the diversity of their targets is still larger than previously thought.
              Article 0 comments Cited 210 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Parasit Vectors
                Title: Parasites & Vectors
                Publisher: BioMed Central
                ISSN (Electronic): 1756-3305
                Publication date Collection: 2011
                Publication date (Electronic): 28 September 2011
                Volume: 4
                Page: 187
                Affiliations
                [1 ]Unité de Parasitologie - UMR6236 - IFR48, Antenne Marseille de l'Institut de Recherche Biomédicale des Armées (IRBA), Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France
                [2 ]Laboratoire de Génétique et Evolution des Maladies infectieuses, UMR 2724 CNRS/IRD, Montpellier, France
                [3 ]Unité d'Entomologie Médicale, Antenne Marseille de l'Institut de Recherche Biomédicale des Armées (IRBA), Le Pharo, BP 60109, 13 262 Marseille Cedex 07, France
                [4 ]Institut Pasteur de Madagascar, B.P. 1274, Ambohitrakely, 101 Antananarivo, Madagascar
                Article
                Publisher ID: 1756-3305-4-187
                DOI: 10.1186/1756-3305-4-187
                PMC ID: 3197560
                PubMed ID: 21951834
                SO-VID: 8d4f3655-37eb-46f6-8929-60fa2351a027
                Copyright © Copyright ©2011 Fontaine et al; licensee BioMed Central Ltd.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 8 April 2011
                Date accepted : 28 September 2011
                Categories
                Subject: Review

                ScienceOpen disciplines: Parasitology
                Data availability:
                ScienceOpen disciplines: Parasitology

                Comments

                Comment on this article

                scite_

                Similar content494

                See all similar

                Cited by87

                See all cited by

                Most referenced authors2,640

                See all reference authors