Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract.

Guo, Xiaowei; Sun, Jiahui; Liu, Lu Tian; Wang, Shuhong; Wu, Lijun; Yang, Chunjuan

doi:10.1016/j.jep.2015.04.008

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Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract.

Author(s): Chunjuan Yang ¹ , Shuhong Wang ¹ , Xiaowei Guo ¹ , Jiahui Sun ¹ , Lu Liu ¹ , Lijun Wu ²

Publication date (Electronic): Jul 01 2015

Journal: Journal of ethnopharmacology

Publisher: Elsevier BV

Keywords: Anthraquinones, Chrysophanol (PubChem CID:10208), Pharmacokinetics, Rat plasma, Semen Cassiae, UHPLC–MS/MS, aloe-emodin (PubChem CID:10207), aurantio-obtusin (PubChem CID:155011), emodin (PubChem CID:3220), obtusifolin (PubChem CID:3083575), physcion (PubChem CID:10639), rhein (PubChem CID:10168)

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Abstract

Semen Cassiae, called Juemingzi in China, is the seed of the annual Cassia obtusifolia L., of the leguminosae family. It has been used as healthy drinks to alleviate constipation and improve eyesight for many years in China.

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Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Jul 01 2015

Volume: 169

Affiliations

[1 ] College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang Distrct., Harbin 150081, PR China.

[2 ] College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang Distrct., Harbin 150081, PR China. Electronic address: wulijun_111@hotmail.com.

Article

Publisher Item ID: S0378-8741(15)00259-7

DOI: 10.1016/j.jep.2015.04.008

PubMed ID: 25907980

SO-VID: 8e0bb37f-b64d-4a6d-915b-9dba2e39a1b3

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Keywords: physcion (PubChem CID:10639),aloe-emodin (PubChem CID:10207),Chrysophanol (PubChem CID:10208),UHPLC–MS/MS,emodin (PubChem CID:3220),rhein (PubChem CID:10168),Pharmacokinetics,obtusifolin (PubChem CID:3083575),Rat plasma,aurantio-obtusin (PubChem CID:155011),Anthraquinones,Semen Cassiae

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Keywords: physcion (PubChem CID:10639), aloe-emodin (PubChem CID:10207), Chrysophanol (PubChem CID:10208), UHPLC–MS/MS, emodin (PubChem CID:3220), rhein (PubChem CID:10168), Pharmacokinetics, obtusifolin (PubChem CID:3083575), Rat plasma, aurantio-obtusin (PubChem CID:155011), Anthraquinones, Semen Cassiae

Simultaneous determination of seven anthraquinones in rat plasma by Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry and pharmacokinetic study after oral administration of Semen Cassiae extract.

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