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      Alzheimer's disease

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      The Lancet
      Elsevier BV

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          Abstract

          Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau. However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the amyloid precursor protein and presenilin genes, both linked to Abeta metabolism. By contrast with familial disease, sporadic Alzheimer's disease is very common with more than 15 million people affected worldwide. The cause of the sporadic form of the disease is unknown, probably because the disease is heterogeneous, caused by ageing in concert with a complex interaction of both genetic and environmental risk factors. This seminar reviews the key aspects of the disease, including epidemiology, genetics, pathogenesis, diagnosis, and treatment, as well as recent developments and controversies.

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          Author and article information

          Journal
          The Lancet
          The Lancet
          Elsevier BV
          01406736
          July 2006
          July 2006
          : 368
          : 9533
          : 387-403
          Article
          10.1016/S0140-6736(06)69113-7
          16876668
          8ebf9df8-89e1-4152-8c4e-843e6f4c2d4e
          © 2006

          https://www.elsevier.com/tdm/userlicense/1.0/

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