The association between constipation and subsequent risk of atopic dermatitis in children: the Japan Environment and Children’s Study

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

No study has examined the association between constipation and atopic dermatitis (AD) in infants and toddlers. We aimed to explore that association in toddlers using the data from a nationwide birth cohort study.

Methods

From the Japan Environment and Children’s Study, a nationwide prospective birth cohort study that began in 2011, children born in a singleton live birth were analyzed. Participants completed questionnaires containing questions related to bowel movements and AD, during 1.5 to 3 years after birth. Constipation at 1 year of age was defined as having ≤2 bowel movements per week. AD was defined based on participant’s responses to the modified ISAAC questionnaire and/or self-reported physician’s diagnosis. Outcome was defined as the cumulative number of AD cases that occurred until 3 years of age. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for development of AD were calculated by a multivariable logistic regression.

Results

From a total of 62,777 participants who met the study inclusion criteria, 14,188 children (22.6%) were affected by AD between the ages of 1.5 and 3 years. The adjusted OR of developing AD for the presence versus absence of constipation at 1 year of age was 1.18 (95% CI, 1.01–1.38).

Conclusion

Constipation at 1 year of age was associated with a slightly higher risk of AD until 3 years of age.

Supplementary information

The online version contains supplementary material available at https://doi.org/10.1265/ehpm.23-00103.

Related collections

Most cited references 22

Record: found
Abstract: found
Article: not found

Atopic dermatitis.

Stephan Weidinger, Natalija Novak (2016)

Atopic dermatitis (also known as atopic eczema) is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. Although it most often starts in infancy and affects two of ten children, it is also highly prevalent in adults. It is the leading non-fatal health burden attributable to skin diseases, inflicts a substantial psychosocial burden on patients and their relatives, and increases the risk of food allergy, asthma, allergic rhinitis, other immune-mediated inflammatory diseases, and mental health disorders. Originally regarded as a childhood disorder mediated by an imbalance towards a T-helper-2 response and exaggerated IgE responses to allergens, it is now recognised as a lifelong disposition with variable clinical manifestations and expressivity, in which defects of the epidermal barrier are central. Present prevention and treatment focus on restoration of epidermal barrier function, which is best achieved through the use of emollients. Topical corticosteroids are still the first-line therapy for acute flares, but they are also used proactively along with topical calcineurin inhibitors to maintain remission. Non-specific immunosuppressive drugs are used in severe refractory cases, but targeted disease-modifying drugs are being developed. We need to improve understanding of the heterogeneity of the disease and its subtypes, the role of atopy and autoimmunity, the mechanisms behind disease-associated itch, and the comparative effectiveness and safety of therapies.

0 comments Cited 393 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Rationale and study design of the Japan environment and children’s study (JECS)

Toshihiro Kawamoto, Hiroshi Nitta, Katsuyuki Murata … (2014)

Background There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better environmental management based on sound science. The primary objective of the Japan Environment and Children’s Study (JECS), a nation-wide birth cohort study that started its recruitment in January 2011, is to elucidate environmental factors that affect children’s health and development. Methods/Design Approximately 100,000 expecting mothers who live in designated study areas will be recruited over a 3-year period from January 2011. Participating children will be followed until they reach 13 years of age. Exposure to environmental factors will be assessed by chemical analyses of bio-specimens (blood, cord blood, urine, breast milk, and hair), household environment measurements, and computational simulations using monitoring data (e.g. ambient air quality monitoring) as well as questionnaires. JECS’ priority outcomes include reproduction/pregnancy complications, congenital anomalies, neuropsychiatric disorders, immune system disorders, and metabolic/endocrine system disorders. Genetic factors, socioeconomic status, and lifestyle factors will also be examined as covariates and potential confounders. To maximize representativeness, we adopted provider-mediated community-based recruitment. Discussion Through JECS, chemical substances to which children are exposed during the fetal stage or early childhood will be identified. The JECS results will be translated to better risk assessment and management to provide healthy environment for next generations.

0 comments Cited 317 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

International study of asthma and allergies in childhood (ISAAC): rationale and methods

M.I. Asher, U Keil, H.R. Anderson … (1995)

The aetiology of asthma and allergic disease remains poorly understood, despite considerable research. The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration. Its specific aims are: 1) to describe the prevalence and severity of asthma, rhinitis and eczema in children living in different centres, and to make comparisons within and between countries; 2) to obtain baseline measures for assessment of future trends in the prevalence and severity of these diseases; and 3) to provide a framework for further aetiological research into genetic, lifestyle, environmental, and medical care factors affecting these diseases. The ISAAC design comprises three phases. Phase 1 uses core questionnaires designed to assess the prevalence and severity of asthma and allergic disease in defined populations. Phase 2 will investigate possible aetiological factors, particularly those suggested by the findings of Phase 1. Phase 3 will be a repetition of Phase 1 to assess trends in prevalence.

0 comments Cited 312 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Tomotaka Sobue: tsobue@envi.med.osaka-u.ac.jp

Journal

Journal ID (nlm-ta): Environ Health Prev Med

Journal ID (iso-abbrev): Environ Health Prev Med

Journal ID (publisher-id): EHPM

Title: Environmental Health and Preventive Medicine

Publisher: Japanese Society for Hygiene

ISSN (Print): 1342-078X

ISSN (Electronic): 1347-4715

Publication date (Electronic, pub): 16 November 2023

Publication date (Electronic, collection): 2023

Volume: 28

Electronic Location Identifier: 71

Affiliations

[1 ]Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita City, Osaka 565-0871, Japan

[2 ]Department of Pediatrics, Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai City, Osaka 593-8304, Japan

[3 ]Osaka Regional Center for Japan Environment and Children’s Study (JECS), Osaka University, 1-3 Yamadaoka Suita City, Osaka 565-0871, Japan

[4 ]Osaka Maternal and Child Health Information Center, Osaka Women’s and Children’s Hospital, 840 Murodo-cho, Izumi City, Osaka 594-1101, Japan

[5 ]Department of Pediatrics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka 565-0871, Japan

[6 ]Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan

Author information

Yoshihiko Takano http://orcid.org/0000-0002-7105-8328

Article

Publisher ID: 23-00103 Other ID: ehpm-28-071

DOI: 10.1265/ehpm.23-00103

PMC ID: 10654214

PubMed ID: 37967924

SO-VID: 8ec65bbb-412a-4430-8114-5b3f980fd7c8

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 24 April 2023

Date accepted : 19 August 2023

Page count

Pages: 6

The association between constipation and subsequent risk of atopic dermatitis in children: the Japan Environment and Children’s Study

Read this article at

Abstract

Background

Methods

Results

Conclusion

Supplementary information

Related collections

Annals of Family Medicine: COVID-19

Most cited references 22

Atopic dermatitis.

Rationale and study design of the Japan environment and children’s study (JECS)

International study of asthma and allergies in childhood (ISAAC): rationale and methods

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Page count

Categories

Comments

Comment on this article

Similar content 411

Most referenced authors 2,010