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      Photobiomodulation Therapy on Orthodontic Movement: Analysis of Preliminary Studies with a New Protocol

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          Abstract

          This study aimed to investigate the effectiveness of photobiomodulation therapy (PBMT) on the acceleration of orthodontic movements, deriving from its biostimulating and regenerative capacity on soft tissues, consequent to the increase in differentiation, proliferation, and activity of cells that are involved with alveolar bone remodeling. The present randomized controlled trial was conducted on six patients who required extractive orthodontic therapy because their ectopic canines had erupted. A total of eight canines were analyzed, four of which received laser irradiation (i.e., experimental group). Two weeks after the extractions, all canines of the experimental and placebo groups were distalized simultaneously and symmetrically with the laceback retraction technique. The PBMT protocol consisted of four cycles of laser applications, one each on days 0, 3, 7, and 14 of the study, with session treatment durations of 2–4 min. The results of the descriptive analysis on the distal displacement speed of the canines after 1 month of follow-up indicate an average displacement of 1.35 mm for the non-irradiated group and 1.98 mm for the irradiated group. Through inferential analysis, a statistically significant difference ( p < 0.05) was found between the average speed of the irradiated canines and the control canines. The low energy density laser used in this study, with the parameters set, was found to be a tool capable of statistically significantly accelerating the distal displacement of canines.

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          Most cited references45

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          The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt.

          The first experimental investigation of orthodontic tooth movement was published by Sandstedt in 1904-1905. After 100 years, there is a good understanding of the sequence of events at both tissue and cellular levels and now the current focus of research is at the molecular level. The techniques of reverse transcription-polymerase chain reaction and in situ hybridization to detect mRNAs of interest have revolutionized tooth movement studies and an expanding list of antibodies and enzyme-linked immunosorbent assays directed against human and animal proteins will facilitate their identification in tissue sections and/or culture supernatants. Nevertheless, although this technology has greatly simplified research for the clinical and laboratory investigator, message is not always translated into protein, and the presence of a protein does not necessarily mean it is biologically active. In vivo and in vitro methods have been widely used in tooth movement studies. However, data from in vitro models, in which the mechanical stimulus can be carefully controlled (tension versus compression; intermittent versus continuous), should be correlated with in vivo data from animal models. The current evidence suggests that downstream from the initial mechanotransduction event at focal adhesions which link the extracellular matrix to the cytoskeleton, mechanically induced remodelling is mediated by a complex feedback mechanism involving the synthesis of cytokines such as interleukin-1 (IL-1), IL-6, and receptor activator of nuclear factor k B ligand by cells of the osteoblast and/or fibroblast lineages. These in turn act in an autocrine/paracrine fashion to regulate the expression of transcription factors, cytokines, growth factors, enzymes, and structural molecules involved in the differentiation, proliferation, and function of mesenchymal and other cell types. Contrary to the impression gained from the literature, tooth movement is not confined to events within the periodontal ligament. Orthodontic tooth movement involves two interrelated processes: (1) deflection or bending of the alveolar bone and (2) remodelling of the periodontal tissues.
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            Meta analysis of the treatment-related factors of external apical root resorption.

            To elucidate possible treatment-related etiological factors--such as, duration of treatment and apical displacement--for external root resorption. Meta-analysis of the available English-language literature. Papers with a sample size > 10, fixed appliances, pre- and post-operative radiographs, and apical displacement recorded were included. History of trauma, prior root resorption and endodontic treatment were excluded. Appropriateness of these selections was tested with a 'funnel plot' analysis. Correlations between root resorption, apical displacement, and treatment duration. Mean apical root resorption was strongly correlated with total apical displacement (r = 0.822) and treatment duration (r = 0.852). The treatment-related causes of root resorption appear to be the total distance the apex had moved and the time it took.
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              Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation.

              The long duration of orthodontic treatment is a major concern for patients. A noninvasive method of accelerating tooth movement in a physiologic manner is needed. The aim of this study was to evaluate of the efficacy of low-intensity laser therapy in reducing orthodontic treatment duration and pain.
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                Author and article information

                Journal
                Int J Environ Res Public Health
                Int J Environ Res Public Health
                ijerph
                International Journal of Environmental Research and Public Health
                MDPI
                1661-7827
                1660-4601
                19 May 2020
                May 2020
                : 17
                : 10
                : 3547
                Affiliations
                Author notes
                Author information
                https://orcid.org/0000-0002-0660-4062
                https://orcid.org/0000-0001-8509-2255
                https://orcid.org/0000-0002-2679-7607
                https://orcid.org/0000-0003-2439-2187
                https://orcid.org/0000-0002-6876-8839
                Article
                ijerph-17-03547
                10.3390/ijerph17103547
                7277382
                32438716
                917a26dd-70dd-4a88-b1d3-a7a8377db078
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 01 April 2020
                : 11 May 2020
                Categories
                Article

                Public health
                pbmt,photobiomodulation therapy,accelerated orthodontic movement,teeth extraction,premolar extraction,ectopic canines

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