For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
146
references
 Top references
cited by
43
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      46
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      CD2 Immunobiology

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effects in vitro and clinical studies have proven the safety and efficacy of CD2-targeting biologics. Investigators have highlighted that the lack of attention to the CD2/LFA3 costimulatory pathway is a missed opportunity. Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more selectively target memory T cells while favoring immune regulation.

          Related collections

          Most cited references146

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy

          Sourav Paul, Girdhari Lal (2017)
          Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells and control the cytolytic function. NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in hematological malignancies but not very promising in solid tumors. Increasing evidence suggests that tumor microenvironment regulate the phenotype and function of NK cells. In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on effector and cytolytic function of NK cells. We also summarized various NK cell-based immunotherapeutic strategies used in the past and the possibilities to improve the function of NK cell for the better clinical outcome.
          Article 0 comments Cited 274 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            A cell atlas of human thymic development defines T cell repertoire formation

            Jong-Eun Park, Rachel Botting, Cecilia Domínguez Conde … (2020)
            The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8αα + T cell populations, thymic fibroblast subtypes, and activated dendritic cell states. In addition, we reveal a bias in TCR recombination and selection, which is attributed to genomic position and the kinetics of lineage commitment. Taken together, our data provide a comprehensive atlas of the human thymus across the life span with new insights into human T cell development.
            Article 0 comments Cited 222 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.

              Todd A Fehniger, Megan A. Cooper, Gerard Nuovo … (2003)
              Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56(bright) NK cells to secrete IFN-gamma. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole.
              Article 0 comments Cited 219 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Immunol
                Journal ID (iso-abbrev): Front Immunol
                Journal ID (publisher-id): Front. Immunol.
                Title: Frontiers in Immunology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1664-3224
                Publication date (Electronic): 09 June 2020
                Publication date Collection: 2020
                Volume: 11
                Electronic Location Identifier: 1090
                Affiliations
                [1] 1Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University , Uppsala, Sweden
                [2] 2Research and Development, ITB-Med AB , Stockholm, Sweden
                [3] 3Department of Medicine, Columbia Center for Translational Immunology, Columbia University Medical Center , New York, NY, United States
                [4] 4Division of Transplantation Surgery, CLINTEC, Karolinska Institute, and Department of Transplantation Surgery, Karolinska University Hospital , Stockholm, Sweden
                Author notes

                Edited by: Michael Loran Dustin, University of Oxford, United Kingdom

                Reviewed by: Paul E. Love, National Institutes of Health (NIH), United States; John Stephen Bridgeman, Immetacyte Ltd, United Kingdom

                *Correspondence: Christian Binder christian.binder@ 123456igp.uu.se

                This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology

                Article
                DOI: 10.3389/fimmu.2020.01090
                PMC ID: 7295915
                PubMed ID: 32582179
                SO-VID: 93832d97-dba7-4ec8-a6e3-2f8b67b89ea4
                Copyright © Copyright © 2020 Binder, Cvetkovski, Sellberg, Berg, Paternina Visbal, Sachs, Berglund and Berglund.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 06 February 2020
                Date accepted : 05 May 2020
                Page count
                Figures: 3, Tables: 0, Equations: 0, References: 159, Pages: 14, Words: 12340
                Categories
                Subject: Immunology
                Subject: Review

                ScienceOpen disciplines: Immunology
                Keywords: cd2,cd58,lfa-3 (lymphocyte functional antigen-3),t cell activation,costimulation,costimulation blockade,alefacept,siplizumab
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: cd2, cd58, lfa-3 (lymphocyte functional antigen-3), t cell activation, costimulation, costimulation blockade, alefacept, siplizumab

                Comments

                Comment on this article

                scite_

                Similar content46

                See all similar

                Cited by43

                See all cited by

                Most referenced authors2,157

                See all reference authors