Renin-Angiotensin-Aldosterone System in Mild Diabetic Nephropathy

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Abstract

The mechanism of lowered renin-aldosterone system was investigated in 17 patients with diabetic nephropathy (serum Cr < 3 mg/l00 ml) with concomitant control of the blood sugar level. The response of plasma renin activity (PRA) to upright stimulation was lower in the low renin group (group I) than in the normal to high renin group (group II) and in the control group. The PRA response to theophylline was delayed in group I. The percentage of the luminal area of the arteriole in the biopsy specimens was larger in group I and the control group than in group II. Plasma aldosterone concentration (PAC) was not increased by angiotensin II in group I. Low PRA in diabetic nephropathy with slightly to moderately impaired renal function may not be due to hyaline destruction of the arteriolar walls, but to other factors such as sympathetic nervous dysfunction. The adrenal responses of PAC to angiotensin II may also be impaired.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1982

Publication date (Print): 1982

Publication date (Electronic): 03 December 2008

Volume: 31

Issue: 4

Pages: 361-367

Affiliations

Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan

Article

Publisher ID: 182682 Other ID: Nephron 1982;31:361–367

DOI: 10.1159/000182682

PubMed ID: 6757774

SO-VID: 9466943f-c417-44c5-98a8-5272d6e0fa01

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Renin-Angiotensin-Aldosterone System in Mild Diabetic Nephropathy

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Abstract

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Karger: Nephrology

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