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      Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy

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      Journal of Neuroscience Methods
      Elsevier BV

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          Abstract

          Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats. Session parameters adopted for use in our laboratory and the considerations relevant to them are described. The strengths and weaknesses of the PR schedule are also discussed.

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          Author and article information

          Journal
          Journal of Neuroscience Methods
          Journal of Neuroscience Methods
          Elsevier BV
          01650270
          May 1996
          May 1996
          : 66
          : 1
          : 1-11
          Article
          10.1016/0165-0270(95)00153-0
          8794935
          94fff3b7-fd9a-49f1-8372-b20930c0ca42
          © 1996

          https://www.elsevier.com/tdm/userlicense/1.0/

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