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Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy
May 1996
May 1996
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Abstract
Drug self-administration studies have recently employed progressive ratio (PR) schedules
to examine psychostimulant and opiate reinforcement. This review addresses the technical,
statistical, and theoretical issues related to the use of the PR schedule in self-administration
studies in rats. Session parameters adopted for use in our laboratory and the considerations
relevant to them are described. The strengths and weaknesses of the PR schedule are
also discussed.