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      Epidemiology of allergic rhinitis and associated risk factors in Asia

      review-article
      ,
      The World Allergy Organization Journal
      BioMed Central
      Allergic rhinitis, Risk factor, Asia, Systematic review

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          Abstract

          This review article aims to present the epidemiology and associated risk factors of allergic rhinitis (AR) in Asia. AR-related literature published on Asia was systematically reviewed and the associated risk factors were investigated.

          The prevalence of AR in Asia varied considerably depending on the geographical location, study design and population involved. Several risk factors were observed to have strong association with disease presentation across multiple studies. Among these, family income, family size, daily personal computer usage time, personal and parental education attainment, and stress level have shown some level of biological gradient influence when multiple risk levels were analyzed. This suggests that AR manifestation and presentation possibly might be strongly affected by various personal and family factors. These findings are beneficial as they may provide insights into modifiable factors that may influence AR presentation. In addition, these results indicate that strategies to reduce personal and family-related risk factors have to be developed in order to alleviate the odds of AR expression.

          Electronic supplementary material

          The online version of this article (10.1186/s40413-018-0198-z) contains supplementary material, which is available to authorized users.

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          Most cited references44

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          Family size, infection and atopy: the first decade of the 'hygiene hypothesis'

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            Substance use disorders in patients with posttraumatic stress disorder: a review of the literature.

            Alcohol use disorders and other substance use disorders are extremely common among patients with posttraumatic stress disorder (PTSD). This article reviews studies pertaining to the epidemiology, clinical phenomenology, and pathophysiology of comorbid PTSD and substance use disorders. Studies were identified by means of computerized and manual searches. The review of research on the pathophysiology of PTSD and substance use disorders was focused on studies of the hypothalamic-pituitary-adrenal axis and the noradrenergic system. High rates of comorbidity suggest that PTSD and substance use disorders are functionally related to one another. Most published data support a pathway whereby PTSD precedes substance abuse or dependence. Substances are initially used to modify PTSD symptoms. With the development of dependence, physiologic arousal resulting from substance withdrawal may exacerbate PTSD symptoms, thereby contributing to a relapse of substance use. Preclinical work has led to the proposal that in PTSD, corticotropin-releasing hormone and noradrenergic systems may interact such that the stress response is progressively augmented. Patients may use sedatives, hypnotics, or alcohol in an effort to interrupt this progressive augmentation. Vigorous control of withdrawal and PTSD-related arousal symptoms should be sought during detoxification of patients with comorbid PTSD and substance use disorders. Inclusion of patients with comorbid PTSD and substance use disorders in neurobiologic research and in clinical trials will be critical for development of effective treatments for this severely symptomatic patient population.
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              Stress and the higher education student: a critical review of the literature

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                Author and article information

                Contributors
                e0002357@u.nus.edu
                dbscft@nus.edu.sg
                Journal
                World Allergy Organ J
                World Allergy Organ J
                The World Allergy Organization Journal
                BioMed Central (London )
                1939-4551
                6 August 2018
                6 August 2018
                2018
                : 11
                : 1
                : 17
                Affiliations
                ISNI 0000 0001 2180 6431, GRID grid.4280.e, Department of Biological Sciences, Faculty of Science, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, , National University of Singapore, ; Block S2, Level 5, Science Drive 4, Lower Kent Ridge Rd, Singapore, 117543 Singapore
                Author information
                http://orcid.org/0000-0003-1337-5146
                Article
                198
                10.1186/s40413-018-0198-z
                6091170
                30128063
                96a25564-5057-4488-876e-88b515dcd652
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 10 January 2018
                : 11 July 2018
                Categories
                Review
                Custom metadata
                © The Author(s) 2018

                Immunology
                allergic rhinitis,risk factor,asia,systematic review
                Immunology
                allergic rhinitis, risk factor, asia, systematic review

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