The aim of the study is to present the efforts of the Greek physicians to introduce a malaria control and eradication program in Greece. It is based on the proceedings of the Greek Anti-Malaria League and on medicohistorical studies. Due to political, economic and military reasons the Greek State seemed weak to develop a dedicated plan to eradicate malaria. Hence, the Greek Anti-Malaria League in 1905 was founded by a group of eminent citizens who took the initiative to organize a campaign against the disease. Constantinos Savvas, Professor of Hygiene and Microbiology and President of the League, as well as the pediatrician Dr. Ioannis Kardamatis were among the most influential personalities in the Greek society at that time. Due to the massive use of quinine the burden of the disease decreased significantly. But, the national disaster of 1922, however, during the Greek-Turkish War and the wave of one million Greek refugees from Asia Minor to Greece modified the epidemiological map of malaria. The heritage of the epidemiological studies undertaken by the League was the basis for the new campaign undertaken during the 1930s by the Greek State and the Rockefeller Foundation. The new structure of the Sanitary Services, the legacy of the League's experience and the knowledge of the Greek trainees of the Rockefeller Foundation, served as the starting-point for the final eradication of malaria after World War II.