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      Pregnancy Outcomes in Women With Rheumatic Mitral Valve Disease : Results From the Registry of Pregnancy and Cardiac Disease

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          Abstract

          Cardiac disease is 1 of the major causes of maternal mortality. We studied pregnancy outcomes in women with rheumatic mitral valve disease.

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          Most cited references20

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          ESC Guidelines for the management of grown-up congenital heart disease (new version 2010).

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            Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice.

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              Acute rheumatic fever and rheumatic heart disease

              Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which can result from a single severe episode or from multiple recurrent episodes of the illness, is known as rheumatic heart disease (RHD) and is a notable cause of morbidity and mortality in resource-poor settings around the world. Although our understanding of disease pathogenesis has advanced in recent years, this has not led to dramatic improvements in diagnostic approaches, which are still reliant on clinical features using the Jones Criteria, or treatment practices. Indeed, penicillin has been the mainstay of treatment for decades and there is no other treatment that has been proven to alter the likelihood or the severity of RHD after an episode of ARF. Recent advances - including the use of echocardiographic diagnosis in those with ARF and in screening for early detection of RHD, progress in developing group A streptococcal vaccines and an increased focus on the lived experience of those with RHD and the need to improve quality of life - give cause for optimism that progress will be made in coming years against this neglected disease that affects populations around the world, but is a particular issue for those living in poverty.
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                Author and article information

                Journal
                Circulation
                Circulation
                Ovid Technologies (Wolters Kluwer Health)
                0009-7322
                1524-4539
                February 20 2018
                February 20 2018
                : 137
                : 8
                : 806-816
                Affiliations
                [1 ]Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands (I.M.v.H., J.W.R.-H.)
                [2 ]Department of Cardiology, Adult Congenital Heart Disease Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom (S.A.T.)
                [3 ]Department of Cardiology, Faculty of Medicine, El Minya University Hospital, Minya, Egypt (N.T.)
                [4 ]Department of Cardiology, Kasr Al Ainy Hospital, Cairo University, Egypt (G.Y.)
                [5 ]Department of Cardiology, Banha University Hospital, Egypt (A.E.)
                [6 ]Department of Cardiology, Medical University of Vienna, Austria (H.G.)
                [7 ]Department of Cardiology, Alexandria University Students Hospital, Alexandria, Egypt (Y.E.R.)
                [8 ]Department of Cardiology, Bichat Hospital, AP-HP, DHU Fire and Paris Diderot University, France (B.I.)
                [9 ]Department of Obstetrics, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom (M.R.J.)
                [10 ]Department of Cardiology, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (R.H.)
                [11 ]Fellow of the ESC, Sophia Antipolis Cedex, Biot, France (J.W.R.-H.).
                Article
                10.1161/CIRCULATIONAHA.117.032561
                29459466
                99c147de-98b9-40d0-98ca-5b09f9d8c7df
                © 2018
                History

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