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      DLEU7-AS1 promotes renal cell cancer by silencing the miR-26a-5p/coronin-3 axis

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          ABSTRACT

          Long non-coding RNAs (lncRNAs) have been implicated in the progression and development of many types of cancer by interacting with RNA, DNA and proteins, including DLEU7-AS1. However, the function of DLEU7-AS1 in renal cell cancer (RCC) remains unclear. In this study, two in silico prediction algorithms were used to discover the potential target of miR-26a-5p, which was determined to be a tumor suppressor gene, possibly DLEU7-AS1, through the downregulation of coronin-3 in RCC. Thus, we hypothesized that DLEU7-AS1 promotes RCC by silencing the miR-26a-5p/coronin-3 axis. To test our hypothesis, we confirmed that DLEU7-AS1 directly targets miR-26a-5p using the pmirGLO dual-luciferase reporter assay. Next, we observed that DLEU7-AS1 expression was markedly upregulated in RCC samples and inversely correlated with clinical prognosis and miR-26a-5p levels. Knockdown of DLEU7-AS1 significantly suppressed the growth and metastasis of RCC cells in vitro and attenuated tumor growth in vivo. Interestingly, exogenous expression of coronin-3 or miR-26a-5p inhibitor treatment almost completely rescued the DLEU7-AS1 knockdown-induced inhibitory effects on cell proliferation, migration and invasion. In conclusion, our data demonstrate that DLEU7-AS1 is an oncogene in RCC capable of regulating the growth and metastasis of RCC by silencing the miR-26a-5p/coronin-3 axis, suggesting that DLEU7-AS1 can be employed as a potential therapeutic target and prognostic biomarker for RCC.

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          Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

          Hyuna Sung, Jacques Ferlay, Rebecca Siegel … (2021)
          This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
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            Long Noncoding RNAs in Cancer Pathways.

            Adam Schmitt, Howard Y. Chang (2016)
            Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.
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              Evolution and functions of long noncoding RNAs.

              Chris P. Ponting, Peter Oliver, Wolf Reik (2009)
              RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they cannot all be dismissed as merely transcriptional "noise." Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease.
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                Author and article information

                Contributors
                Xin-jun Wang
                Lin Chen
                Ran Xu
                Si Li
                Guang-cheng Luo
                Journal
                Journal ID (nlm-ta): Clin Kidney J
                Journal ID (iso-abbrev): Clin Kidney J
                Journal ID (publisher-id): ckj
                Title: Clinical Kidney Journal
                Publisher: Oxford University Press
                ISSN (Print): 2048-8505
                ISSN (Electronic): 2048-8513
                Publication date Collection: August 2022
                Publication date (Electronic): 28 February 2022
                Publication date PMC-release: 28 February 2022
                Volume: 15
                Issue: 8
                Pages: 1542-1552
                Affiliations
                Department of Urology, Zhongshan Hospital Xiamen University, School of medicine, Xiamen University , Xiamen, Fujian, China
                The Third Clinical Medical College, Fujian Medical University , Fuzhou, Fujian, China
                The Third Clinical Medical College, Fujian Medical University , Fuzhou, Fujian, China
                Department of Urology, Zhongshan Hospital Xiamen University, School of medicine, Xiamen University , Xiamen, Fujian, China
                Department of Urology, Zhongshan Hospital Xiamen University, School of medicine, Xiamen University , Xiamen, Fujian, China
                Department of Urology, Zhongshan Hospital Xiamen University, School of medicine, Xiamen University , Xiamen, Fujian, China
                Department of Urology, Zhongshan Hospital Xiamen University, School of medicine, Xiamen University , Xiamen, Fujian, China
                The Third Clinical Medical College, Fujian Medical University , Fuzhou, Fujian, China
                Author notes
                Correspondence to: Guang-cheng Luo; E-mail: lgch@ 123456xmu.edu.cn
                Article
                Publisher ID: sfac061
                DOI: 10.1093/ckj/sfac061
                PMC ID: 9308101
                PubMed ID: 35892027
                SO-VID: 9b66a031-97f4-44cc-b81c-1733a90ad887
                Copyright © © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@ 123456oup.com

                History
                Date received : 28 January 2022
                Page count
                Pages: 11
                Funding
                Funded by: Science and Technology Bureau of Xiamen;
                Award ID: 3502Z20184033
                Award ID: 3502Z20194022
                Funded by: Natural Science Foundation of Fujian Province, DOI 10.13039/501100003392;
                Award ID: 2020J011213
                Funded by: Fujian Provincial Health Commission, DOI 10.13039/501100014125;
                Funded by: Xiamen Health and Family Planning Commission;
                Award ID: 2021GGB028
                Categories
                Subject: Original Article
                Subject: AcademicSubjects/MED00340

                ScienceOpen disciplines: Nephrology
                Keywords: coronin-3,dleu7-as1,mir-26a-5p,renal cell cancer
                Data availability:
                ScienceOpen disciplines: Nephrology
                Keywords: coronin-3, dleu7-as1, mir-26a-5p, renal cell cancer

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