There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies and recombinant proteins, poses substantial challenges owing to their large size and susceptibility to degradation. In this Review we highlight recent advances in formulation and delivery strategies--such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs--and discuss their advantages and limitations. We also highlight current and emerging delivery routes that provide an alternative to injection, including transdermal, oral and pulmonary delivery routes. In addition, the potential of targeted and intracellular protein delivery is discussed.
Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.
Abbreviated Title:
Expert Opinion on Drug Delivery
Publisher:
Informa UK Limited
ISSN
(Print):
1742-5247
ISSN
(Electronic):
1744-7593
Publication date
(Electronic):
April
12 2022
Pages: 1-18
Affiliations
[1
]Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology,
School of Therapeutic Science, Faculty of Health Sciences, University of the Witwatersrand,
Johannesburg, 7 York Road 2193, Parktown, South Africa