Apo(a) Phenotypes and Lp(a) Concentrations in Renal Transplant Patients

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Abstract

Plasma lipoprotein (a) (LP(a)) concentrations are increased in patients with end-stage renal disease. Considering the influence of the apolipoprotein (a) (Apo(a)) polymorphism and the mode of dialysis in this prospective longitudinal study, we compared Lp(a) concentrations before and after the first 6 months of a successful kidney transplantation in 125 recipient patients. Apo(a) phenotyping was performed by using SDS-PAGE and SDS-agarose, isoforms were classified into high molecular weight (HMW) and low molecular weight (LMW). Before the graft, the Lp(a) concentrations were significantly higher in CAPD than in hemodialysis patients (p = 0.021). Six months after transplantation, Lp(a) fell in both treatment groups. This decrease occurred within both LMW and HMW but to a different extent: median relative variations were –35 and –50%, respectively (p = 0.048). Among patients with Lp(a) concentration >30 mg/dl 6 months after transplantation, 74% had LMW Apo(a) isoform while the remaining 26% had HMW isoform. Successful renal transplantation leads rapidly to a correction of Lp(a) concentrations, especially in patients treated with CAPD who have higher Lp(a) levels. The most important factor seems to be the LMW status corresponding to high Lp(a) levels.

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Most cited references 2

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Identification of 34 apolipoprotein(a) isoforms: differential expression of apolipoprotein(a) alleles between American blacks and whites.

Marcel Albers, Martin Y H Zhang, V Gaur … (1993)

A total of 34 different apo(a) isoforms was identified in a population sample of 806 American Whites and 701 American Blacks by a high resolution SDS-agarose gel electrophoretic method followed by immunoblotting. Among the 1507 individuals tested, 79% revealed double-banded phenotypes and 21% single-banded phenotypes. The frequencies of the apo(a) isoforms differed between American Blacks and Whites (p < 0.001).

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Hyperlipidemia in adult, pediatric and diabetic renal transplant recipients

Lloyd Ibels, Alle C Alfrey, Richard Weil (1978)

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1998

Publication date (Print): October 1998

Publication date (Electronic): 23 September 1998

Volume: 80

Issue: 2

Pages: 183-187

Affiliations

Laboratoire de Recherches Néphrologiques, Hôpital Calmette, Lille, France

Article

Publisher ID: 45164 Other ID: Nephron 1998;80:183–187

DOI: 10.1159/000045164

PubMed ID: 9736817

SO-VID: 9bf0a5f0-2b77-4d83-be59-03cb69dc03d1

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