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      Effect of cyclodextrin charge on complexation of neutral and charged substrates: comparison of (SBE)7M-beta-CD to HP-beta-CD.

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      Journal: Pharmaceutical Research

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          Abstract

          To understand the role of charge in substrate/cyclodextrin complexation by comparing the binding of neutral and charged substrates to a neutral cyclodextrin, such as hydroxypropyl beta-CD (HP-beta-CD) with 3.5 degrees of substitution, and an anionically charged cyclodextrin, such as sulfobutyl ether beta-CD ((SBE)7M-beta-CD) with 6.8 degrees of substitution.

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          PubMed ID:: 11465424
          DOI:: 10.1023/A

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