For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
21
views
33
references
 Top references
cited by
8
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      416
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Synthesis and In vitro cytotoxic activity evaluation of ( E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background and the purpose of the study

          Modified androsterone derivatives are class of steroidal compounds with potential anticancer properties. Various steroidal derivatives containing substitution at position 16 have shown diversified pharmacological activities. In the present study, a new series of cytotoxic 16-(substituted benzylidene) derivatives of dehydroepiandrosterone (DHEA) were synthesized and evaluated against three different cancer cell lines.

          Methods

          The cytotoxic 16-(substituted benzylidene) derivatives of DHEA were synthesized via aldol condensation of DHEA with corresponding benzaldehyde derivatives. The cytotoxic activity of synthesized derivatives was evaluated against three different cancer cells including KB, T47D and SK-N-MC cell lines by MTT reduction colorimetric assay.

          Results

          The results indicated that 16-(substituted benzylidene) derivatives of DHEA could be served as a potent anti-cancer agent. The 3-cholro benzylidene derivatives of DHEA was the most potent synthesized derivative especially against KB and T47D cell lines (IC 50 values were 0.6 and 1.7 μM; respectively).

          Conclusion

          The cytotoxic potential of novel benzylidene derivatives of DHEA is mainly attributed to the position and nature of the substituted group on the benzylidene pendant.

          Related collections

          Most cited references33

          • Record: found
          • Abstract: found
          • Article: not found

          Sex hormones and hypertension.

          Suzanne Oparil, Bruno Imthurn, Simon Jackson … (2002)
          Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian hormones may modulate blood pressure. However, whether sex hormones are responsible for the observed gender-associated differences in arterial blood pressure and whether ovarian hormones account for differences in blood pressure in premenopausal versus postmenopausal women remains unclear. In this review, we provide a discussion of the potential blood pressure regulating effects of female and male sex hormones, as well as the cellular, biochemical and molecular mechanisms by which sex hormones may modify the effects of hypertension on the cardiovascular system.
          Article 0 comments Cited 105 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Association between plasma prolactin concentrations and risk of breast cancer among predominately premenopausal women.

            Shelley S. Tworoger, P Sluss, Sue Hankinson (2006)
            Recent evidence suggests that prolactin may be positively associated with postmenopausal breast cancer risk; however, little data are available in younger women. Therefore, we conducted a prospective, nested case-control study to examine the relationship between plasma prolactin concentrations and breast cancer risk in predominately premenopausal women from the Nurses' Health Study II. Blood samples were collected from 1996 to 1999. The analysis includes 316 cases of breast cancer diagnosed after blood donation and before June 1, 2003, who had two controls matched on age, fasting status, time of day and month of blood collection, race/ethnicity, and timing of blood draw within the menstrual cycle. Sixty-three percent of participants provided a timed follicular and luteal menstrual phase blood sample; other women provided a single untimed sample. When including all women, we observed a positive association between prolactin and breast cancer risk [relative risk (RR), top quartile versus bottom quartile, 1.5; 95% confidence interval (95% CI), 1.0-2.3; P(trend) = 0.03] that was slightly stronger among estrogen receptor-positive/progesterone receptor-positive tumors (comparable RR, 1.9; 95% CI, 1.1-3.3; P(trend) = 0.04). Associations were similar among premenopausal women only. However, we did not find an association between prolactin and breast cancer risk among the subset of women who only provided timed samples (comparable RR, average of timed samples, 1.3; 95% CI, 0.8-2.3; P(trend) = 0.40). The association seemed stronger among women > or = 45 years old and for cases diagnosed within approximately 4 years of blood collection. Our data suggest a modest positive association between prolactin and breast cancer risk among predominately premenopausal women; however, further follow-up is needed to increase power for subgroup analyses.
            Article 0 comments Cited 54 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Biological transformations of steroidal compounds: a review.

              Haq Bhatti, Rasheed Khera (2012)
              Microbial transformation is an important tool for structural modification of organic compounds, especially natural products with complex structures like steroids. It can be used to synthesize chemical structures that are difficult to obtain by ordinary methods and as a model of mammalian metabolism due to similarity between mammalian and microbial enzyme systems. During recent years research has been focused on the structural modifications of bioactive steroids by using various microorganisms, in order to obtain biologically potent compounds with diverse structures. Steroidal compounds are responsible for important biological functions in the cells and manifest a variety of activities. This article covers the microbial transformation of sterols, steroidal hormones and some new types of steroids known as bufadienolides. Emphasis has placed on reporting metabolites that may be of general interest and on the practical aspects of work in the field of microbial transformations. The review covers the literature from 1994 to 2011. Copyright © 2012 Elsevier Inc. All rights reserved.
              Article 0 comments Cited 35 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Mohsen Vosooghi
                Hoda Yahyavi
                Kouros Divsalar
                Hashem Shamsa
                Asma Kheirollahi
                Maliheh Safavi
                Sussan Kabudanian Ardestani
                Sareh Sadeghi-Neshat
                Negar Mohammadhosseini
                Najmeh Edraki
                Mehdi Khoshneviszadeh
                Abbas Shafiee
                Alireza Foroumadi
                Journal
                Journal ID (nlm-ta): Daru
                Journal ID (iso-abbrev): Daru
                Title: DARU Journal of Pharmaceutical Sciences
                Publisher: BioMed Central
                ISSN (Print): 1560-8115
                ISSN (Electronic): 2008-2231
                Publication date Collection: 2013
                Publication date (Electronic): 1 May 2013
                Volume: 21
                Issue: 1
                Page: 34
                Affiliations
                [1 ]Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
                [2 ]Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
                [3 ]Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, P.O. Box 13145–1384, Tehran, Iran
                [4 ]Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
                Article
                Publisher ID: 2008-2231-21-34
                DOI: 10.1186/2008-2231-21-34
                PMC ID: 3673839
                PubMed ID: 23635011
                SO-VID: 9cf0dc3b-df4f-4181-9786-2ee3449c8e10
                Copyright © Copyright © 2013 Vosooghi et al.; licensee BioMed Central Ltd.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 March 2013
                Date accepted : 21 April 2013
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: synthesis,dehydroepiandrosterone (dhea),mtt assay,cytotoxic activity
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: synthesis, dehydroepiandrosterone (dhea), mtt assay, cytotoxic activity

                Comments

                Comment on this article

                scite_

                Similar content416

                See all similar

                Cited by8

                See all cited by

                Most referenced authors295

                See all reference authors