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      Phyllanthus niruri Inhibits Calcium Oxalate Endocytosis by Renal Tubular Cells: Its Role in Urolithiasis

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      Nephron

      S. Karger AG

      Phyllanthus niruri, Calcium oxalate, Madin-Darby canine kidney cells, Endocytosis, Renal stone

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          Abstract

          We investigated the in vitro effect of an aqueous extract of Phyllanthus niruri L. on a model of CaOx crystal endocytosis by Madin-Darby canine kidney cells. The extract exhibited a potent and effective non-concentration-dependent inhibitory effect on the CaOx crystal internalization. This response was present even at very high (pathologic) CaOx concentrations and no P. niruri L.-induced toxic effect could be detected. Biochemical analysis of culture media containing P. niruri L. did not provide any clues for the elucidation of the cellular pathways affected by this natural product. Although further studies are necessary for a better understanding of the role of P. niruri L. in urolithiasis, our findings show that this natural product could be an attractive alternative for the treatment of urinary stones.

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          Most cited references 3

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          Medicinal plants in tropical West Africa. III. Anti-infection therapy with higher plants.

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            Usage and bioassays in Phyllanthus (Euphorbiaceae): a compilation. III. The subgenera Eriococcus, Conami, Gomphidium, Botryanthus, Xylophylla and Phyllanthodendron, and a complete list of the species cited in the three-part series.

            References to either indigenous uses or the results of controlled assays are numerous for species of Phyllanthus (Euphorbiaceae). These citations have been arranged by subgenus, section, subsection and species and will be published in four papers, including (in Part IV) analysis, discussion and conclusions concerning apparent clustering of some uses or effects within taxa. This paper (Part III) covers the subgenera Eriococcus, Conami, Gomphidium, Botryanthus, Xylophylla and Phyllanthodendron, and also includes a list of the species cited in this three-part series.
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              The Dependence on Membrane Fluidity of Calcium Oxalate Crystal Attachment to IMCD Membranes

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1999
                April 1999
                31 March 1999
                : 81
                : 4
                : 393-397
                Affiliations
                Nephrology Division, Department of Medicine, Universidade Federal de São Paulo, Brazil
                Article
                45322 Nephron 1999;81:393–397
                10.1159/000045322
                10095174
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 3, Tables: 1, References: 17, Pages: 5
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45322
                Categories
                Original Paper

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