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Abstract
An iridium photoredox catalyst in combination with either a stoichiometric amount
of Brønsted acid or a catalytic amount of Lewis acid is capable of catalyzing regioselective
alkylation of N-heteroarenes with N-(acyloxy)phthalimides at room temperature under
irradiation. A broad range of N-heteroarenes can be alkylated using a variety of secondary,
tertiary, and quaternary carboxylates. Mechanistic studies suggest that an IrII /IrIII
redox catalytic cycle is responsible for the observed reactivity.