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      An aerobiological perspective in allergy and asthma

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          Abstract

          Allergic diseases are amongst the most common chronic disorders worldwide. Today, more than 300 million of the population is known to suffer from one or other allergic ailments affecting the socio-economic quality of life. Major causative agents implicated are pollen grains, fungal spores, dust mites, insect debris, animal epithelia, etc. Several aerobiological studies have been conducted in different parts of the world to ascertain aerial concentration and seasonality of pollen grains and fungi. Especially from clinical point of view, it is important to know the details about the pollen season and pollen load in the atmosphere. The flowering time of higher plants are events that come periodically in each season, but the time of blooming may differ from year to year, in different geographic locations. Based on differences recorded in several years of observations in airborne pollen, pollen calendars are drawn as an aid to allergy diagnosis and management. This review article emphasises on various aerobiological parameters of environmental pollen from different parts of the world with special emphasis from India. The role of aerobiology in the diagnosis and management of allergic diseases is reviewed briefly in this article.

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          Most cited references162

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          Fungi as a cause of allergic disease.

          S Gravesen (1979)
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            Influence of outdoor aeroallergens on hospitalization for asthma in Canada.

            The risk of hospitalization for asthma caused by outdoor aeroallergens is largely unknown. The objective of this study was to determine the association between changes in outdoor aeroallergens and hospitalizations for asthma from the Pacific coast to the Atlantic coast of Canada. A daily time series analysis was done to test the association between daily changes in aeroallergens and daily changes in hospitalizations for asthma during a 7-year period between 1993 and 2000 in 10 of the largest cities in Canada. Results were adjusted for long-term trends, day of the week, climate, and air pollution. A daily increase, equivalent to the mean value of each allergen, was associated with the following percentage increase in asthma hospitalizations: 3.3% (95% CI, 2.3 to 4.1) for basidiomycetes, 3.1% (95% CI, 2.8 to 5.7) for ascomycetes, 3.2% (95% CI, 1.6 to 4.8) for deuteromycetes, 3.0% (95% CI, 1.1 to 4.9) for weeds, 2.9% (95% CI, 0.9 to 5.0) for trees, and 2.0% (95% CI, 1.1 to 2.8) for grasses. After accounting for the independent effects of trees and ozone, the combination of the 2 was associated with an additional 0.22% increase in admissions averaged across cities (P <.05). These findings provide evidence for the hypothesis that aeroallergens are an important cause of severe asthma morbidity across Canada, and in some situations there might be a modest synergistic adverse effect of ozone and aeroallergens combined.
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              Degree and clinical relevance of sensitization to common allergens among adults: a population study in Helsinki, Finland.

              We aimed to assess the prevalence of allergic sensitization and multiple sensitization, risk factors, and the clinical impact of being sensitized in the adult population of Helsinki, Finland. As a part of the FinEsS study, a population-based random sample of 498 adults aged 26-60 years were tested for 15 common aeroallergens with skin prick tests (SPTs) and interviewed on respiratory symptoms and diseases, including respiratory irritants and childhood environment. The prevalence of at least one positive prick test was 46.9%. A large difference by age was found: 56.8% were sensitized among those aged 26-39 years, 49.2% in the age group 40-49 years, and 35.6% in the age group 50-60 years (P<0.001). Sensitization to multiple allergens was common among young subjects with 42% of the sensitized responding to at least four allergens, while this proportion was only 16% of the sensitized among those aged 50-60 years. The prevalence of physician-diagnosed asthma, allergic rhinitis (AR) or conjunctivitis, and wheeze increased significantly with increasing number of positive responses to SPTs. Having a family history of AR or conjunctivitis was a significant risk factor for allergic sensitization and for sensitization to any of the pollens. Further, urban living in childhood yielded an increased risk for pollen sensitization. The prevalence of allergic sensitization was high in the urban adult population of Helsinki. More than half of those aged 26-39 years was sensitized and 24% was sensitized to at least four allergens. Sensitization to multiple allergens was associated with a high prevalence of asthma, AR or conjunctivitis, and wheeze.
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                Author and article information

                Journal
                Asia Pac Allergy
                Asia Pac Allergy
                APA
                Asia Pacific Allergy
                Asia Pacific Association of Allergy, Asthma and Clinical Immunology
                2233-8276
                2233-8268
                July 2012
                25 July 2012
                : 2
                : 3
                : 210-222
                Affiliations
                Allergy & Aerobiology Laboratory, Institute of Genomics & Integrative Biology, Delhi University Campus, Delhi 110007, India.
                Author notes
                Correspondence: Anand Bahadur Singh. Allergy & Aerobiology Laboratory, Institute of Genomics & Integrative Biology, Delhi University Campus, Delhi 110007, India. Tel: +91-11-27666156, Fax: +91-11-27667471, singha49@ 123456hotmail.com
                Article
                10.5415/apallergy.2012.2.3.210
                3406301
                22872824
                9ffa8d3c-92af-41ef-87fc-0d4d476fe3c5
                Copyright © 2012. Asia Pacific Association of Allergy, Asthma and Clinical Immunology.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 12 June 2012
                : 09 July 2012
                Categories
                Educational & Teaching Material

                Immunology
                pollen,allergens,allergy,seasonal variations,aerobiology,asthma
                Immunology
                pollen, allergens, allergy, seasonal variations, aerobiology, asthma

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