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      The association between self-rated health and all-cause mortality and explanatory factors in China’s oldest-old population

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          Abstract

          Background

          Self-rated health (SRH) is considered a condensed summary of information about bodily conditions that involves people’s biological, cognitive, and cultural status, but has been under-studied in the oldest old population. This study aimed to investigate the association between SRH and all-cause mortality among the oldest-old population in China and to explore potential explanatory factors in this association.

          Methods

          The study was based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 1998 to 2018 and included 30 222 participants aged 80 years or older (ie, the oldest old) in the analysis. We used Cox models to assess the association between SRH and mortality in this population and its subgroups, and used the Percentage Excess Risk Mediated approach to identify potential contributing factors.

          Results

          After adjustment of confounders, people with “good” “neutral”, and “bad/very bad” SRH were significantly associated with 8% (95% confidence interval (CI) = 3%-13%), 23% (95% CI = 18%-29%), and 52% (95% CI = 44%-61%) higher hazard of mortality respectively, compared with those with “very good” SRH. The significant SRH-mortality associations were exclusive to men and those with at least primary education. The adjustment of “regular physical activity”, “leisure activity”, “activities of daily living (ADL)”, and “cognitive function” all led to noticeable attenuation to the SRH-mortality association, with “leisure activity” causing the most attenuation (64.9%) in the “Good SRH” group.

          Conclusions

          Self-rated health is significantly associated with all-cause mortality among the oldest old population in China, particularly among men and the educated, and is considerably explained by regular physical activity, leisure activity, ADL, and cognitive function. We advocate the use of SRH as a simple and efficient tool in research and (potentially) health care practices.

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          Most cited references25

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          What is self-rated health and why does it predict mortality? Towards a unified conceptual model.

          The association of self-rated health with mortality is well established but poorly understood. This paper provides new insights into self-rated health that help integrate information from different disciplines, both social and biological, into one unified conceptual framework. It proposes, first, a model describing the health assessment process to show how self-rated health can reflect the states of the human body and mind. Here, an analytic distinction is made between the different types of information on which people base their health assessments and the contextual frameworks in which this information is evaluated and summarized. The model helps us understand why self-ratings of health may be modified by age or culture, but still be a valid measure of health status. Second, based on the proposed model, the paper examines the association of self-rated health with mortality. The key question is, what do people know and how do they know what they know that makes self-rated health such an inclusive and universal predictor of the most absolute biological event, death. The focus is on the social and biological pathways that mediate information from the human organism to individual consciousness, thus incorporating that information into self-ratings of health. A unique source of information is provided by the bodily sensations that are directly available only to the individual him- or herself. According to recent findings in human biology, these sensations may reflect important physiological dysregulations, such as inflammatory processes. Third, the paper discusses the advantages and limitations of self-rated health as a measure of health in research and clinical practice. Future research should investigate both the logics that govern people's reasoning about their health and the physiological processes that underlie bodily feelings and sensations. Self-rated health lies at the cross-roads of culture and biology, therefore a collaborative effort between different disciplines can only improve our understanding of this key measure of health status.
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            Contribution of risk factors to excess mortality in isolated and lonely individuals: an analysis of data from the UK Biobank cohort study

            Summary Background The associations of social isolation and loneliness with premature mortality are well known, but the risk factors linking them remain unclear. We sought to identify risk factors that might explain the increased mortality in socially isolated and lonely individuals. Methods We used prospective follow-up data from the UK Biobank cohort study to assess self-reported isolation (a three-item scale) and loneliness (two questions). The main outcomes were all-cause and cause-specific mortality. We calculated the percentage of excess risk mediated by risk factors to assess the extent to which the associations of social isolation and loneliness with mortality were attributable to differences between isolated and lonely individuals and others in biological (body-mass index, systolic and diastolic blood pressure, and handgrip strength), behavioural (smoking, alcohol consumption, and physical activity), socioeconomic (education, neighbourhood deprivation, and household income), and psychological (depressive symptoms and cognitive capacity) risk factors. Findings 466 901 men and women (mean age at baseline 56·5 years [SD 8·1]) were included in the analyses, with a mean follow-up of 6·5 years (SD 0·8). The hazard ratio for all-cause mortality for social isolation compared with no social isolation was 1·73 (95% CI 1·65–1·82) after adjustment for age, sex, ethnic origin, and chronic disease (ie, minimally adjusted), and was 1·26 (95% CI 1·20–1·33) after further adjustment for socioeconomic factors, health-related behaviours, depressive symptoms, biological factors, cognitive performance, and self-rated health (ie, fully adjusted). The minimally adjusted hazard ratio for mortality risk related to loneliness was 1·38 (95% CI 1·30–1·47), which reduced to 0·99 (95% CI 0·93–1·06) after full adjustment for baseline risks. Interpretation Isolated and lonely people are at increased risk of death. Health policies addressing risk factors such as adverse socioeconomic conditions, unhealthy lifestyle, and lower mental wellbeing might reduce excess mortality among the isolated and the lonely. Funding Academy of Finland, NordForsk, and the UK Medical Research Council.
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              5 year mortality predictors in 498,103 UK Biobank participants: a prospective population-based study.

              To our knowledge, a systematic comparison of predictors of mortality in middle-aged to elderly individuals has not yet been done. We investigated predictors of mortality in UK Biobank participants during a 5 year period. We aimed to investigate the associations between most of the available measurements and 5 year all-cause and cause-specific mortality, and to develop and validate a prediction score for 5 year mortality using only self-reported information.
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                Author and article information

                Journal
                J Glob Health
                J Glob Health
                JGH
                Journal of Global Health
                International Society of Global Health
                2047-2978
                2047-2986
                23 July 2022
                2022
                : 12
                : 11005
                Affiliations
                [1 ]Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China
                [2 ]The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
                [3 ]Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
                [4 ]Baylor College of Medicine, Houston, Texas, USA
                [5 ]MindRank AI ltd., Hangzhou, Zheijang, China
                [6 ]Nossal Institute for Global Health, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
                [7 ]School of population medicine and public health, China Academy of Medical Science & Peking Union Medical College, Beijing, China
                [8 ]Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
                [9 ]Duke Global Health Institute, Duke University, Durham, North Carolina, USA
                [10 ]Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
                [11 ]The George Institute for Global Health, Beijing, China
                [12 ]School of Public Health, Wuhan University, Wuhan, China
                Author notes
                [*]

                Equal contributions as first-authors.

                Correspondence to:
Lijing L Yan
Kunshan
Jiangsu
P.R.China
 lijing.yan@ 123456duke.edu 
Shangzhi Xiong
Kunshan
Jiangsu
P.R.China
 shangzhi.xiong@ 123456duke.edu
                Article
                jogh-12-11005
                10.7189/jogh.12.11005
                9305379
                35866355
                a0e4ec5f-629b-48b8-a885-7e386a8166f6
                Copyright © 2022 by the Journal of Global Health. All rights reserved.

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Page count
                Figures: 3, Tables: 2, Equations: 0, References: 29, Pages: 10
                Categories
                Research Theme 7: Health Transitions in China

                Public health
                Public health

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