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      The Risk of Renal Stone Formation during and after Long Duration Space Flight

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          Background: The formation of a renal stone during space flight may have serious negative effects on the health of the crewmember and the success of the mission. Urinary biochemical factors and the influence of dietary factors associated with renal stone development were assessed during long duration Mir Space Station missions. Methods: Twenty-four-hour urine samples were collected prior to, during and following long duration space flight. The relative urinary supersaturation of calcium oxalate, calcium phosphate (brushite), sodium urate, struvite and uric acid were determined. Results: Changes in the urinary biochemistry of crewmembers during long duration spaceflight demonstrated increases in the supersaturation of the stone-forming salts. In-flight hypercalciuria was evident in a number of individual crewmembers and 24-hour dietary fluid intake and urine volume were significantly lower. During flight, there was a significant increase in brushite supersaturation. Conclusions: These data suggest acute effects of space flight and postflight changes in the urinary biochemistry favoring increased crystallization in the urine. The effects of dietary intake, especially fluid intake, may have a significant impact on the potential for renal stone formation. Efforts are now underway to assess the efficacy of a countermeasure to mitigate the increased risk.

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          Author and article information

          S. Karger AG
          10 October 2001
          : 89
          : 3
          : 264-270
          aNASA/Johnson Space Center and bWyle Life Sciences, Houston, Tex., USA cInstitute for Biomedical Problems, Moscow, Russia
          46083 Nephron 2001;89:264–270
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 1, Tables: 2, References: 21, Pages: 7
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/46083
          Original Paper

          Cardiovascular Medicine, Nephrology

          Aerospace medicine, Renal stone, Space flight


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