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      Deploying efficient net batch normalizations (BNs) for grading diabetic retinopathy severity levels from fundus images

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          Abstract

          Diabetic retinopathy (DR) is one of the main causes of blindness in people around the world. Early diagnosis and treatment of DR can be accomplished by organizing large regular screening programs. Still, it is difficult to spot diabetic retinopathy timely because the situation might not indicate signs in the primary stages of the disease. Due to a drastic increase in diabetic patients, there is an urgent need for efficient diabetic retinopathy detecting systems. Auto-encoders, sparse coding, and limited Boltzmann machines were used as a few past deep learning (DL) techniques and features for the classification of DR. Convolutional Neural Networks (CNN) have been identified as a promising solution for detecting and classifying DR. We employ the deep learning capabilities of efficient net batch normalization (BNs) pre-trained models to automatically acquire discriminative features from fundus images. However, we successfully achieved F1 scores above 80% on all efficient net BNs in the EYE-PACS dataset (calculated F1 score for DeepDRiD another dataset) and the results are better than previous studies. In this paper, we improved the accuracy and F1 score of the efficient net BNs pre-trained models on the EYE-PACS dataset by applying a Gaussian Smooth filter and data augmentation transforms. Using our proposed technique, we have achieved F1 scores of 84% and 87% for EYE-PACS and DeepDRiD.

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          Most cited references41

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          A global review of publicly available datasets for ophthalmological imaging: barriers to access, usability, and generalisability

          Health data that are publicly available are valuable resources for digital health research. Several public datasets containing ophthalmological imaging have been frequently used in machine learning research; however, the total number of datasets containing ophthalmological health information and their respective content is unclear. This Review aimed to identify all publicly available ophthalmological imaging datasets, detail their accessibility, describe which diseases and populations are represented, and report on the completeness of the associated metadata. With the use of MEDLINE, Google's search engine, and Google Dataset Search, we identified 94 open access datasets containing 507 724 images and 125 videos from 122 364 patients. Most datasets originated from Asia, North America, and Europe. Disease populations were unevenly represented, with glaucoma, diabetic retinopathy, and age-related macular degeneration disproportionately overrepresented in comparison with other eye diseases. The reporting of basic demographic characteristics such as age, sex, and ethnicity was poor, even at the aggregate level. This Review provides greater visibility for ophthalmological datasets that are publicly available as powerful resources for research. Our paper also exposes an increasing divide in the representation of different population and disease groups in health data repositories. The improved reporting of metadata would enable researchers to access the most appropriate datasets for their needs and maximise the potential of such resources.
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            Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution

            Hyperpolarized 129 Xe NMR/MRI is a useful method for diagnosis of diseases of the respiratory system. However, the sensitive detection of specific compounds in blood remains a challenge because of the weak 129 Xe signal in aqueous solution. We developed a way, Hyper-SAME, to promote the 129 Xe signal in aqueous solution. The 129 Xe signal intensity is four times beyond that of free 129 Xe in water and 200 times better than the benchmark molecular cage, cryptophane-A, in its saturated aqueous solution. Additionally, the hyperpolarized 129 Xe signal can be amplified further by combining Hyper-SAME with hyperpolarized 129 Xe chemical exchange saturation transfer. We report hyperpolarized Xe signal advancement by metal-organic framework (MOF) entrapment (Hyper-SAME) in aqueous solution. The 129 Xe NMR signal is drastically promoted by entrapping the Xe into the pores of MOFs. The chemical shift of entrapped 129 Xe is clearly distinguishable from that of free 129 Xe in water, due to the surface and pore environment of MOFs. The influences from the crystal size of MOFs and their concentration in water are studied. A zinc imidazole MOF, zeolitic imidazole framework-8 (ZIF-8), with particle size of 110 nm at a concentration of 100 mg/mL, was used to give an NMR signal with intensity four times that of free 129 Xe in water. Additionally, Hyper-SAME is compatible with hyperpolarized 129 Xe chemical exchange saturation transfer. The 129 Xe NMR signal can be amplified further by combining the two techniques. More importantly, Hyper-SAME provides a way to make detection of hyperpolarized 129 Xe in aqueous solution convenient and broadens the application area of MOFs.
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              Deep Learning based Computer-Aided Diagnosis Systems for Diabetic Retinopathy: A Survey

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                Author and article information

                Contributors
                scientificresearchglobe@gmail.com
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                2 September 2023
                2 September 2023
                2023
                : 13
                : 14462
                Affiliations
                [1 ]GRID grid.412117.0, ISNI 0000 0001 2234 2376, National University of Sciences and Technology, ; Islamabad, 44000 Pakistan
                [2 ]GRID grid.413060.0, ISNI 0000 0000 9957 3191, Mechanical Engineering Department, College of Engineering, , University of Bahrain, ; Isa Town, 32038 Bahrain
                [3 ]GRID grid.411323.6, ISNI 0000 0001 2324 5973, Depaetment of Mechanical Engineering, , Lebanese American University, ; Kraytem, Beirut, 1102-2801 Lebanon
                [4 ]GRID grid.414839.3, ISNI 0000 0001 1703 6673, Department of Mathematics and Statistics, , Riphah International University I-14, ; Islamabad, 44000 Pakistan
                [5 ]GRID grid.11135.37, ISNI 0000 0001 2256 9319, Department of Mechanics and Engineering Science, , Peking University, ; Beijing, 100871 China
                [6 ]GRID grid.440865.b, ISNI 0000 0004 0377 3762, Faculty of Engineering, Center of Research, , Future University in Egypt, ; New Cairo, 11835 Egypt
                [7 ]GRID grid.56302.32, ISNI 0000 0004 1773 5396, Department of Quantitative Analysis, College of Business Administration, , King Saud University, ; P.O. Box 71115, 11587 Riyadh, Saudi Arabia
                Article
                41797
                10.1038/s41598-023-41797-9
                10475020
                37660096
                a41ace06-b26a-4ad8-9fcd-e19d63e60aea
                © Springer Nature Limited 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 25 March 2023
                : 31 August 2023
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                © Springer Nature Limited 2023

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                health care,energy science and technology
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                health care, energy science and technology

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