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      Wnt/beta-catenin signaling: components, mechanisms, and diseases.

      1 , ,
      Developmental cell
      Elsevier BV

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          Abstract

          Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery that mediates beta-catenin-dependent transcription. Finally, we highlight some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications.

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          Author and article information

          Journal
          Dev Cell
          Developmental cell
          Elsevier BV
          1878-1551
          1534-5807
          Jul 2009
          : 17
          : 1
          Affiliations
          [1 ] F. M. Kirby Neurobiology Center, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
          Article
          S1534-5807(09)00257-3 NIHMS196288
          10.1016/j.devcel.2009.06.016
          2861485
          19619488
          aa038019-4bfd-4c41-a485-bf416139ab8a
          History

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