Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation.

Jain, Manish; Singh, Ankita; Singh, Vishal; Maurya, Preeti; Barthwal, Manoj Kumar

doi:10.1177/1074248415598003

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Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation.

Author(s): Manish Jain ¹ , Ankita Singh ¹ , Vishal Singh ¹ , Preeti Maurya ¹ , Manoj Kumar Barthwal ²

Publication date (Electronic): Mar 2016

Journal: Journal of cardiovascular pharmacology and therapeutics

Publisher: SAGE Publications

Keywords: endothelial dysfunction, neointimal hyperplasia, p27Kip1, p38 MAPK, vascular smooth muscle cell proliferation

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Abstract

Gingerol inhibits growth of cancerous cells; however, its role in vascular smooth muscle cell (VSMC) proliferation is not known. The present study investigated the effect of gingerol on VSMC proliferation in cell culture and during neointima formation after balloon injury.

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Journal ID (iso-abbrev): J. Cardiovasc. Pharmacol. Ther.

Title: Journal of cardiovascular pharmacology and therapeutics

Publisher: SAGE Publications

ISSN (Electronic): 1940-4034

ISSN (Print): 1074-2484

Publication date (Electronic): Mar 2016

Volume: 21

Issue: 2

Affiliations

[1 ] Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

[2 ] Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India manojbarthwal@cdri.res.in.

Article

Publisher Item ID: 1074248415598003

DOI: 10.1177/1074248415598003

PubMed ID: 26240073

SO-VID: aa3f8cd9-6c4a-4fbf-8bae-f7af6ce9413c

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Keywords: vascular smooth muscle cell proliferation,p38 MAPK,neointimal hyperplasia,p27Kip1,endothelial dysfunction

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Keywords: vascular smooth muscle cell proliferation, p38 MAPK, neointimal hyperplasia, p27Kip1, endothelial dysfunction

Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation.

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Vascular Biology

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