Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma.

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Abstract

The functions of hypoxia and subsequent hypoxia-inducible factor-1α (HIF-1α) activation in vasculogenic mimicry (VM) are currently unclear. This study aimed to investigate the effects of hypoxia on VM formation in ovarian cancer, and explore the possible mechanism involved.

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Journal

Journal ID (iso-abbrev): Gynecol Oncol

Title: Gynecologic oncology

Publisher: Elsevier BV

ISSN (Electronic): 1095-6859

ISSN (Print): 0090-8258

Publication date (Electronic): Jun 2014

Volume: 133

Issue: 3

Affiliations

[1 ] Department of Pathology, Tianjin Medical University, Tianjin 300070, PR China; Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300070, PR China; Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, PR China.

[2 ] Department of Pathology, Tianjin Medical University, Tianjin 300070, PR China; Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300070, PR China; Department of Pathology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, PR China. Electronic address: baocunsun@gmail.com.

[3 ] Department of Pathology, Tianjin Medical University, Tianjin 300070, PR China; Department of Pathology, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, PR China.

[4 ] Department of Pathology, Tianjin Medical University, Tianjin 300070, PR China.

Article

Publisher Item ID: S0090-8258(14)00179-6

DOI: 10.1016/j.ygyno.2014.02.034

PubMed ID: 24589413

SO-VID: aac53667-b77f-486d-9744-feb94b933b89

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Keywords: Epithelial–mesenchymal transition,HIF-1α,Hypoxia,Ovarian cancer,Vasculogenic mimicry

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Keywords: Epithelial–mesenchymal transition, HIF-1α, Hypoxia, Ovarian cancer, Vasculogenic mimicry

Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma.

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