Photosensitized formation of 8-hydroxydeoxyguanosine in cellular DNA by riboflavin.

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Abstract

Photosensitized formation of 8-hydroxydeoxyguanosine (oh8dG) in DNA by riboflavin has recently been shown in vitro. The present study describes the formation of oh8dG in cellular DNA by photo-irradiation of cultured mammalian cells in the presence of riboflavin. Formation of oh8dG was dependent on the concentration of riboflavin as well as the duration of photoirradiation. These results suggest that photosensitized formation of oh8dG in DNA by riboflavin may be involved in photocarcinogenesis.

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Journal

Journal ID (iso-abbrev): Biochem. Biophys. Res. Commun.

Title: Biochemical and biophysical research communications

ISSN: 0006-291X

ISSN (Print): 0006-291X

Publication date (Electronic): Sep 16 1992

Volume: 187

Issue: 2

Affiliations

[1 ] Biology Division, National Cancer Center Research Institute, Tokyo, Japan.

Article

Publisher Item ID: 0006-291X(92)91268-U

DOI: 10.1016/0006-291X(92)91268-U

PubMed ID: 1530636

SO-VID: ab29d07f-3157-4fb0-b860-0f1b1f2673d5

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