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Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia.
Laura A Vitale
1 ,
Li-Zhen He ,
Lawrence J Thomas ,
Jennifer Widger ,
Jeffrey Weidlick ,
Andrea Crocker ,
Thomas O'Neill ,
James Storey ,
Martin J Glennie ,
Deanna M Grote ,
Stephen M Ansell ,
Henry Marsh ,
Tibor Keler
Jul 15 2012
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Abstract
The TNF receptor superfamily member CD27 is best known for its important role in T-cell immunity but is also recognized as a cell-surface marker on a number of B- and T-cell malignancies. In this article, we describe a novel human monoclonal antibody (mAb) specific for CD27 with properties that suggest a potential utility against malignancies that express CD27.