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      The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods

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          Abstract

          An expert panel was convened in September 2019 by The International Scientific Association for Probiotics and Prebiotics (ISAPP) to develop a definition for fermented foods and to describe their role in the human diet. Although these foods have been consumed for thousands of years, they are receiving increased attention among biologists, nutritionists, technologists, clinicians and consumers. Despite this interest, inconsistencies related to the use of the term ‘fermented’ led the panel to define fermented foods and beverages as “foods made through desired microbial growth and enzymatic conversions of food components”. This definition, encompassing the many varieties of fermented foods, is intended to clarify what is (and is not) a fermented food. The distinction between fermented foods and probiotics is further clarified. The panel also addressed the current state of knowledge on the safety, risks and health benefits, including an assessment of the nutritional attributes and a mechanistic rationale for how fermented foods could improve gastrointestinal and general health. The latest advancements in our understanding of the microbial ecology and systems biology of these foods were discussed. Finally, the panel reviewed how fermented foods are regulated and discussed efforts to include them as a separate category in national dietary guidelines.

          Abstract

          Although fermented foods have been consumed for thousands of years, a clear definition has been lacking. This Consensus Statement outlines a definition for the term ‘fermented foods’ as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in September 2019.

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          Most cited references180

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          Diet rapidly and reproducibly alters the human gut microbiome

          Long-term diet influences the structure and activity of the trillions of microorganisms residing in the human gut 1–5 , but it remains unclear how rapidly and reproducibly the human gut microbiome responds to short-term macronutrient change. Here, we show that the short-term consumption of diets composed entirely of animal or plant products alters microbial community structure and overwhelms inter-individual differences in microbial gene expression. The animal-based diet increased the abundance of bile-tolerant microorganisms (Alistipes, Bilophila, and Bacteroides) and decreased the levels of Firmicutes that metabolize dietary plant polysaccharides (Roseburia, Eubacterium rectale, and Ruminococcus bromii). Microbial activity mirrored differences between herbivorous and carnivorous mammals 2 , reflecting trade-offs between carbohydrate and protein fermentation. Foodborne microbes from both diets transiently colonized the gut, including bacteria, fungi, and even viruses. Finally, increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids, and the outgrowth of microorganisms capable of triggering inflammatory bowel disease 6 . In concert, these results demonstrate that the gut microbiome can rapidly respond to altered diet, potentially facilitating the diversity of human dietary lifestyles.
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            Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic.

            An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics. It is now 13 years since the definition of probiotics and 12 years after guidelines were published for regulators, scientists and industry by the Food and Agriculture Organization of the United Nations and the WHO (FAO/WHO). The FAO/WHO definition of a probiotic--"live microorganisms which when administered in adequate amounts confer a health benefit on the host"--was reinforced as relevant and sufficiently accommodating for current and anticipated applications. However, inconsistencies between the FAO/WHO Expert Consultation Report and the FAO/WHO Guidelines were clarified to take into account advances in science and applications. A more precise use of the term 'probiotic' will be useful to guide clinicians and consumers in differentiating the diverse products on the market. This document represents the conclusions of the ISAPP consensus meeting on the appropriate use and scope of the term probiotic.
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              Revised Estimates for the Number of Human and Bacteria Cells in the Body

              Reported values in the literature on the number of cells in the body differ by orders of magnitude and are very seldom supported by any measurements or calculations. Here, we integrate the most up-to-date information on the number of human and bacterial cells in the body. We estimate the total number of bacteria in the 70 kg "reference man" to be 3.8·1013. For human cells, we identify the dominant role of the hematopoietic lineage to the total count (≈90%) and revise past estimates to 3.0·1013 human cells. Our analysis also updates the widely-cited 10:1 ratio, showing that the number of bacteria in the body is actually of the same order as the number of human cells, and their total mass is about 0.2 kg.
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                Author and article information

                Contributors
                hutkins@unl.edu
                Journal
                Nat Rev Gastroenterol Hepatol
                Nat Rev Gastroenterol Hepatol
                Nature Reviews. Gastroenterology & Hepatology
                Nature Publishing Group UK (London )
                1759-5045
                1759-5053
                4 January 2021
                4 January 2021
                2021
                : 18
                : 3
                : 196-208
                Affiliations
                [1 ]GRID grid.27860.3b, ISNI 0000 0004 1936 9684, Department of Food Science and Technology, , University of California-Davis, ; Davis, CA USA
                [2 ]International Scientific Association for Probiotics and Prebiotics, Centennial, CO USA
                [3 ]GRID grid.17089.37, University of Alberta, Department of Agricultural, Food and Nutritional Science, ; Edmonton, Canada
                [4 ]GRID grid.22072.35, ISNI 0000 0004 1936 7697, Department of Physiology and Pharmacology, , International Microbiome Center, University of Calgary, ; Calgary, Canada
                [5 ]GRID grid.6435.4, ISNI 0000 0001 1512 9569, Teagasc Food Research Centre, ; Moorepark, Ireland
                [6 ]GRID grid.7872.a, ISNI 0000000123318773, APC Microbiome Ireland, University College Cork, ; Cork, Ireland
                [7 ]VistaMilk, Cork, Ireland
                [8 ]GRID grid.8767.e, ISNI 0000 0001 2290 8069, Research Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, ; Brussels, Belgium
                [9 ]GRID grid.7872.a, ISNI 0000000123318773, APC Microbiome Ireland and School of Microbiology, University College Cork, ; Cork, Ireland
                [10 ]GRID grid.411957.f, ISNI 0000 0004 0647 2543, Advanced Green Energy and Environment Institute, Handong Global University, ; Pohang, Gyeongbuk South Korea
                [11 ]GRID grid.5284.b, ISNI 0000 0001 0790 3681, Department of Bioscience Engineering, , University of Antwerp, ; Antwerp, Belgium
                [12 ]GRID grid.213910.8, ISNI 0000 0001 1955 1644, Department of Family Medicine, , Georgetown University, ; Washington, DC USA
                [13 ]GRID grid.39381.30, ISNI 0000 0004 1936 8884, Lawson Health Research Institute, and Departments of Microbiology & Immunology and Surgery, University of Western Ontario, ; London, Ontario Canada
                [14 ]GRID grid.429997.8, ISNI 0000 0004 1936 7531, Department of Biology, , Tufts University, ; Medford, MA USA
                [15 ]GRID grid.24434.35, ISNI 0000 0004 1937 0060, Department of Food Science and Technology, , University of Nebraska - Lincoln, ; Lincoln, NE USA
                Author information
                http://orcid.org/0000-0001-6321-3423
                http://orcid.org/0000-0003-0972-928X
                http://orcid.org/0000-0002-5465-9068
                http://orcid.org/0000-0002-8527-1445
                http://orcid.org/0000-0001-9658-5696
                http://orcid.org/0000-0003-1206-5947
                Article
                390
                10.1038/s41575-020-00390-5
                7925329
                33398112
                ad9236e9-bee2-4ebf-8bb3-530b0e78c5c5
                © The authors 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 11 October 2020
                Categories
                Consensus Statement
                Custom metadata
                © Springer Nature Limited 2021

                microbiome,colon
                microbiome, colon

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