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      An unusual presentation of a more common disease entity

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          Abstract

          A 66-year-old, male patient with a 10-pack-year history of smoking was referred to the internal medicine consultation because of a 4-week history of fatigue, weakness, intermittent low-grade fever, appetite and weight loss, and a mild dry cough. His previous history was unremarkable and his physical examination was normal. Routine laboratory screening revealed leukocytosis (11.08×10 9 leukocytes per L), elevated C-reactive protein (72.1 mg⋅L −1) and erythrocyte sedimentation rate 57 mm⋅h −1. Analyses for rheumatoid factor, antinuclear antibodies, and cytoplasmic and perinuclear anti-neutrophil cytoplasmic antibodies were all negative. Pulmonary function tests (static and dynamic volumes, flow–volume curve, and lung diffusion capacity) were within the predictive values. Chest radiography demonstrated bilateral hilar enlargement. The patient subsequently underwent a computed tomography (CT) scan of the chest (figure 1).

          Abstract

          Beware unusual presentations of more common disease entities, as in this interactive case report http://ow.ly/qj7f30eVFsp

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          Most cited references18

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          Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society.

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            Bronchiolitis obliterans organizing pneumonia.

            In 50 of 94 patients with bronchiolitis obliterans we found no apparent cause or associated disease, and the bronchiolitis obliterans occurred with patchy organizing pneumonia. Histologic characteristics included polypoid masses of granulation tissue in lumens of small airways, alveolar ducts, and some alveoli. The fibrosis was uniform in age, suggesting that all repair had begun at the same time. The distribution was patchy, with preservation of background architecture. Clinically, there was cough or flu-like illness for 4 to 10 weeks, and crackles were heard in the lungs of 68 per cent of the patients. Radiographs showed an unusual pattern of patchy densities with a "ground glass" appearance in 81 per cent. Physiologically, there was restriction in 72 per cent of the patients, and 86 per cent had impaired diffusing capacity. Obstruction was limited to smokers. The mean follow-up period was four years. With corticosteroids, there was complete clinical and physiologic recovery in 65 per cent of the subjects; two died from progressive disease. This disorder differs from bronchiolitis obliterans with irreversible obstruction. It was confused most often with idiopathic pulmonary fibrosis. In view of the benign course and therapeutic response, a histologic distinction is important.
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              Organising pneumonia.

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                Author and article information

                Journal
                Breathe (Sheff)
                Breathe (Sheff)
                BREATHE
                breathe
                Breathe
                European Respiratory Society
                1810-6838
                2073-4735
                March 2018
                : 14
                : 1
                : 49-53
                Affiliations
                [1 ]Respiratory diseases, Universitaire Ziekenhuizen Leuven, Leuven, Belgium
                [2 ]Radiology, Universitaire Ziekenhuizen Leuven, Leuven, Belgium
                [3 ]Dept of Pathology, KU Leuven, Leuven, Belgium
                [4 ]Nuclear Medicine, Universitaire Ziekenhuizen Leuven, Leuven, Belgium
                [5 ]Respiratory Oncology, University Hospital Gasthuisberg, Leuven, Belgium
                Author notes
                Article
                EDU-0134-2017
                10.1183/20734735.013417
                5831344
                af5b8fda-cada-4a78-8bbb-0d6abe4d8518
                Copyright ©ERS 2018

                Breathe articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

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                Expert Opinion
                Case Report
                18

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