Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

[RNA world and its evolution].

Molekuliarnaia biologiia

metabolism, genetics, RNA, Evolution, Molecular, Esterification, Biogenesis

Read this article at

ScienceOpenPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      The early idea of A. N. Belozersky on the precedence of RNA in the origin of life on Earth is developed. Basing on the present knowledge of functional omnipotence of RNA, the author considers three novel mechanisms that could play a critical role in the origin and evolution of the ancient RNA world: (1) the reaction of spontaneous transesterification of polyribonucleotides in aqueous media, discovered by A.B. Chetverin, which could result in elongation of primary short oligoribonucleotides and generation of sequence variants for subsequent selection; (2) compartmentation of functional RNA ensembles in the form of mixed molecular colonies on moist solid surfaces, in the absence of membranes and any other coats; (3) systematic exponential enrichment of RNA population in functionally "the best" molecules by means of alternately dissolving the colonies upon flooding and forming new ones upon drying a pool ("primordial natural SELEX").

      Related collections

      Author and article information

      Journal
      16083004

      Chemistry

      metabolism, genetics, RNA, Evolution, Molecular, Esterification, Biogenesis

      Comments

      Comment on this article